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Yoda 1

Yoda 1 是Piezo1激动剂，能够激活纯化的 Piezo1 通道。

CAS号

448947-81-7

分子式

C13H8Cl2N4S2

主要靶点

Piezo Channel

仅限科研使用

Cat No : CM05988

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Synonyms

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  • CAS No.: 448947-81-7

    Yoda 1
    CAS#: 448947-81-7

产品信息

Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells, respectively)

CAS号 448947-81-7
分子式 C13H8Cl2N4S2
主要靶点 Piezo Channel
主要通路 离子通道
分子量 355.27
纯度 99.98%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

human Piezo1-transfected HEK293T cells:26.6 μM|Piezo1-transfected HEK293T cells:17.1 μM

体外活性

Yoda1 that acts as an agonist for both human and mouse Piezo1.?Functional studies in cells revealed that Yoda1 affects the sensitivity and the inactivation kinetics of mechanically induced responses[1].

溶解度

DMSO:28 mg/mL (80 mM),Sonification is recommended.

参考文献

1.Ruhma S , Jie X , Dubin A E , et al. Chemical activation of the mechanotransduction channel Piezo1[J]. eLife, 2015, 4.
2.Davies JE, Lopresto D, Apta BHR,et al.Using Yoda-1 to mimic laminar flow in vitro: A tool to simplify drug testing[J].Biochem Pharmacol. 2019 Oct;168:473-480.

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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