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验证数据展示

  • WB analysis of mouse colon using 67389-1-Ig (same clone as 67389-1-PBS)

    WB analysis of mouse colon using 67389-1-Ig (same clone as 67389-1-PBS)

    mouse colon tissue were subjected to SDS PAGE followed by western blot with 67389-1-Ig (ZG16 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67389-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse pancreas using 67389-1-Ig (same clone as 67389-1-PBS)

    IHC staining of mouse pancreas using 67389-1-Ig (same clone as 67389-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse pancreas tissue slide using 67389-1-Ig (ZG16 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67389-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse pancreas using 67389-1-Ig (same clone as 67389-1-PBS)

    IHC staining of mouse pancreas using 67389-1-Ig (same clone as 67389-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse pancreas tissue slide using 67389-1-Ig (ZG16 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67389-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse small intestine using 67389-1-Ig (same clone as 67389-1-PBS)

    IF Staining of mouse small intestine using 67389-1-Ig (same clone as 67389-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse small intestine tissue using ZG16 antibody (67389-1-Ig, Clone: 1A7B9 ) at dilution of 1:400 and CoraLite®594-Conjugated Goat Anti-Mouse IgG(H+L), ASCT2 antibody (20350-1-AP, green), CoraLite® Plus 647 smooth muscle actin specific antibody (CL647-80008, Clone: 5H7, Magenta). This data was developed using the same antibody clone with 67389-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse small intestine using 67389-1-Ig (same clone as 67389-1-PBS)

    IF Staining of mouse small intestine using 67389-1-Ig (same clone as 67389-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse small intestine tissue using ZG16 antibody (67389-1-Ig, Clone: 1A7B9 ) at dilution of 1:400 and CoraLite®594-Conjugated Goat Anti-Mouse IgG(H+L), ASCT2 antibody (20350-1-AP, green), CoraLite® Plus 647 smooth muscle actin specific antibody (CL647-80008, Clone: 5H7, Magenta). This data was developed using the same antibody clone with 67389-1-PBS in a different storage buffer formulation.

ZG16 Monoclonal antibody, PBS Only

ZG16 Monoclonal Antibody for WB, IHC, IF-P, Indirect ELISA
Cat No. 67389-1-PBS

产品说明书

CloneNo. 1A7B9

宿主/亚型

Mouse / IgG1

种属反应性

Human, mouse, pig, rat

应用

WB, IHC, IF-P, Indirect ELISA

别名

FLJ43571, FLJ92276, hZG16, JCLN, JCLN1, Secretory lectin ZG16, ZG16, ZG16A, Zymogen granule protein 16

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

67389-1-PBS targets ZG16 in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with Human, mouse, pig, rat samples.

经测试应用 WB, IHC, IF-P, Indirect ELISA Application Description
经测试反应性 Human, mouse, pig, rat
免疫原 ZG16 fusion protein Ag11332 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 zymogen granule protein 16 homolog (rat)
别名 FLJ43571, FLJ92276, hZG16, JCLN, JCLN1, Secretory lectin ZG16, ZG16, ZG16A, Zymogen granule protein 16
计算分子量 167 aa, 18 kDa
观测分子量 16 kDa
GenBank蛋白编号BC029149
基因名称 ZG16
Gene ID (NCBI) 653808
RRIDAB_2882633
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDO60844
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Zymogen granule protein 16 (ZG16) has a Jacalin-like lectin domain, which is mainly expressed by mucus-secreting cells, including goblet cells in the intestine. It's reported that ZG16 expression was significantly decreased in colorectal cancer compared to normal tissue. ZG16 gene expression and copy number variations (CNV) were associated with multiple molecular and clinicopathological features of CRC including MSI, MLH1 silencing and so on. It's found that ZG16 is negatively correlated with lymphatic invasive and distant metastasis. Besides, overexpression of ZG16 blocks PD-L1 expression in colorectal cancer, and promotes NK cells survival and proliferation. Very importantly, ZG16 suppresses colorectal tumor growth via the immune system. (PMID: 33360840, 21893569)