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ChromoTek anti-IL28a recombinant VHH, biotinylated

IL28-b is a recombinant mono-biotinylated anti IL28 Nanobody (VHH), suitable for ELISA, SPR, and BLI applications.

Host/Type

Alpaca VHH

Reactivity

Human

Applications

BLI, SPR, ELISA

Conjugate

Biotin

Cat No : IL28a-b

Synonyms

IL-28a VHH, IL-28a single domain antibody (sdAb), Interferon Lambda 2, IFNL2, Cytokine Zcyto20

Validation Data Gallery

  • BLI analysis of the capture of varying concentrations of HumanKine IL-28A (HZ-1235) by biotinylated anti-IL-28A VHH (IL28a-b). Please note the higher apparent affinity owing to avidity effects (dimerization of the cytokine).

    BLI analysis of the capture of varying concentrations of HumanKine IL-28A (HZ-1235) by biotinylated anti-IL-28A VHH (IL28a-b). Please note the higher apparent affinity owing to avidity effects (dimerization of the cytokine).

  • ELISA analysis of the capture of varying concentrations of HumanKine IL-28A (HZ-1235) by biotinylated anti-IL-28A VHH (IL28a-b). Detection via rabbit polyclonal PTG 22646-1-AP.

    ELISA analysis of the capture of varying concentrations of HumanKine IL-28A (HZ-1235) by biotinylated anti-IL-28A VHH (IL28a-b). Detection via rabbit polyclonal PTG 22646-1-AP.

Product Information

IL28-b is a recombinant mono-biotinylated anti IL28 Nanobody (VHH), suitable for ELISA, SPR, and BLI applications.

ApplicationsBLI, SPR, ELISA
ReactivityHuman
ConjugateBiotin
TypeNanobody
ClassRecombinant
HostAlpaca
Affinity9 nM
Molecular Weight15.0 kDa
FormLiquid
RRIDAB_3665400
Storage Buffer10 mM HEPES pH 7.0, 500 mM NaCl, 5 mM EDTA, 0.09% sodium azide
Storage ConditionStore at -20°C
Shippingambient
BackgroundIL28A, also named as IFNL2 and ZCYT020, is a cytokine with immunomodulatory activity. It up-regulates MHC class I antigen expression. IL28A is a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. It plays a significant role in the antiviral immune defense in the intestinal epithelium.