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ChromoTek anti-IL28a recombinant VHH, for 1x Cys conjugation

IL28Cys1 is an unconjugated recombinant anti IL28 Nanobody (VHH). Suitable for for dual cysteine conjugation with thiol-reactive reagents, e.g. maleimides. Note: unconjugated VHHs are not suited for usage without prior labeling, since they contain reactive Cysteines. Shipment and storage buffers contain TCEP to keep Cysteines reduced.

Host/Type

Alpaca VHH

Reactivity

Human

Applications

Conjugation

Conjugate

Unconjugated

Cat No : IL28aCys1

Synonyms

IL-28a VHH, IL-28a single domain antibody (sdAb), Interferon Lambda 2, IFNL2, Cytokine Zcyto20

Validation Data Gallery

  • BLI analysis of the interaction between varying concentrations of anti-IL-28A VHH and immobilised, biotinylated HumanKine IL-28A (HZ-1235). Fit indicates fitting of data to a 1:1 binding model.

    BLI analysis of the interaction between varying concentrations of anti-IL-28A VHH and immobilised, biotinylated HumanKine IL-28A (HZ-1235). Fit indicates fitting of data to a 1:1 binding model.

Product Information

IL28Cys1 is an unconjugated recombinant anti IL28 Nanobody (VHH). Suitable for for dual cysteine conjugation with thiol-reactive reagents, e.g. maleimides. Note: unconjugated VHHs are not suited for usage without prior labeling, since they contain reactive Cysteines. Shipment and storage buffers contain TCEP to keep Cysteines reduced.

ApplicationsConjugation
ReactivityHuman
ConjugateUnconjugated
TypeNanobody
ClassRecombinant
HostAlpaca
Affinity9 nM
Molecular Weight15.0 kDa
FormLiquid
RRIDAB_3665399
Storage Buffer10 mM HEPES pH 7.0, 500 mM NaCl, 0.09% sodium azide
Storage ConditionStore at -20°C
Shippingdry ice
BackgroundIL28A, also named as IFNL2 and ZCYT020, is a cytokine with immunomodulatory activity. It up-regulates MHC class I antigen expression. IL28A is a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. It plays a significant role in the antiviral immune defense in the intestinal epithelium.