验证数据展示
产品信息
66576-1-PBS targets c-Cbl in WB, IHC, Indirect ELISA applications and shows reactivity with Human samples.
经测试应用 | WB, IHC, Indirect ELISA Application Description |
经测试反应性 | Human |
免疫原 | c-Cbl fusion protein Ag23033 种属同源性预测 |
宿主/亚型 | Mouse / IgG1 |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | Cas-Br-M (murine) ecotropic retroviral transforming sequence |
别名 | C CBL, CBL, CBL2, c-Cbl, Proto oncogene c Cbl, RING finger protein 55, RNF55 |
计算分子量 | 906 aa, 100 kDa |
观测分子量 | 100-120 kDa |
GenBank蛋白编号 | BC132733 |
基因名称 | CBL |
Gene ID (NCBI) | 867 |
RRID | AB_2881936 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | P22681 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
c-Cbl (Casitas B-lineage lymphoma) is a critical regulator that controls immature or follicular helper T cell development, B cell development, immune tolerance, angiogenesis, or tumorigenesis (PMID: 33962939). c-Cbl also plays a pivotal role in regulating dendritic cell (DC) function via negatively modulating IL-12 production after Toll-like receptor (TLR) stimulation (PMID: 21799517).