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cAC 253 acetate

cAC 253 acetate (TP2135 Free base) 是 amylin 的拮抗剂，抑制 125I-adrenomedullin 结合，其IC50 值为 25 nM。

CAS号

TP2135L

分子式

C128H206N42O42S2

主要靶点

Amylin Receptor

仅限科研使用

Cat No : CM09449

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Synonyms

cAC 253 acetate (TP2135 Free base)

验证数据展示

  • CAS No.: TP2135L

    cAC 253 acetate
    CAS#: TP2135L

产品信息

cAC 253 acetate is an amylin antagonist. cAC 253 acetate inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM.

CAS号 TP2135L
分子式 C128H206N42O42S2
主要靶点 Amylin Receptor
主要通路 G蛋白偶联受体
分子量 3069.39
纯度 99.99%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 cAC 253 acetate (TP2135 Free base)

体外活性

cAC 253 acetate (5-20 μM) antagonizes adrenomedullin-stimulated cAMP production at micromolar concentrations[1]. cAC 253 acetate (5-10 μM) blocks increases in intracellular Ca2+, activation of protein kinase A, MAPK, Akt, cFos, and cell death, which occur upon AMY3 activation with hAmylin, Aβ1-42, or their co-application[2]. cAC 253 acetate (10 nM) blocks Aβ1-42-induced electrophysiological effects[3].

参考文献

1.H A Coppock, et al. Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity. Biochem J. 1999 Feb 15;33 2.Wen Fu, ET AL. Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways. J Biol Chem. 2012 May 25;287(22):18820-30. 3.Jack H Jhamandas, et al. Actions of β-amyloid protein on human neurons are expressed through the amylin receptor. Am J Pathol. 2011 Jan;178(1):140-9.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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