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cIAP1 Monoclonal antibody, PBS Only

cIAP1 Monoclonal Antibody for WB,Indirect ELISA,IHC,IF

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse, rat, pig

Applications

WB,Indirect ELISA,IHC,IF

Conjugate

Unconjugated

CloneNo.

1H3F1

Cat No : 66626-1-PBS

Print datasheet

Synonyms

API1, BIRC2, C IAP1, cIAP1, Hiap 2, HIAP2, IAP 2, IAP homolog B, IAP2, MIHB, RING finger protein 48, RNF48

验证数据展示

  • WB analysis using 66626-1-Ig (same clone as 66626-1-PBS)

    WB analysis using 66626-1-Ig (same clone as 66626-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 66626-1-Ig (cIAP1 antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66626-1-PBS in a different storage buffer formulation.

  • IHC staining of human spleen using 66626-1-Ig (same clone as 66626-1-PBS)

    IHC staining of human spleen using 66626-1-Ig (same clone as 66626-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 66626-1-Ig (cIAP1 antibody) at dilution of 1:300 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66626-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with BIRC2/cIAP1 antibody included
  • IHC staining of human spleen using 66626-1-Ig (same clone as 66626-1-PBS)

    IHC staining of human spleen using 66626-1-Ig (same clone as 66626-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 66626-1-Ig (cIAP1 antibody) at dilution of 1:300 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66626-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with BIRC2/cIAP1 antibody included
  • IF Staining of HepG2 using 66626-1-Ig (same clone as 66626-1-PBS)

    IF Staining of HepG2 using 66626-1-Ig (same clone as 66626-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using 66626-1-Ig (cIAP1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66626-1-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy BIRC2/cIAP1 Ready-To-Use IHC Kit. BIRC2/cIAP1 primary antibody included.

产品信息

66626-1-PBS targets cIAP1 in WB, IF, IHC, Indirect ELISA applications and shows reactivity with Human, mouse, rat, pig samples.

Tested Applications WB,Indirect ELISA,IHC,IF Application Description
Tested Reactivity Human, mouse, rat, pig
Immunogen cIAP1 fusion protein Ag21398 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name baculoviral IAP repeat-containing 2
Synonyms API1, BIRC2, C IAP1, cIAP1, Hiap 2, HIAP2, IAP 2, IAP homolog B, IAP2, MIHB, RING finger protein 48, RNF48
Calculated Molecular Weight 618 aa, 70 kDa
Observed Molecular Weight 70 kDa
GenBank Accession NumberBC016174
Gene Symbol BIRC2
Gene ID (NCBI) 329
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ13490
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

BIRC2 (also known as cIAP1) is a member of the inhibitor of apoptosis protein (IAP) family. The inhibitor of apoptosis (IAP) proteins are a family of anti-apoptotic regulators found in viruses and metazoans. BIRC2 is a nuclear shuttling protein, whose subcellular localization is mediated by the CRM1-dependent nuclear export pathway (PMID: 15265700). The protein is regulated transcriptionally and can be inhibited by mitochondrial proteins released in the cytoplasm upon apoptotic stimuli (PMID: 15187025). BIRC2 is also believed to be a critical regulator of vascular integrity and endothelial cell survival, thereby providing an additional target pathway for the control of angiogenesis and blood vessel homeostasis during embryogenesis, regeneration and tumorigenesis (PMID: 17934460).