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验证数据展示

  • WB analysis using 21860-1-AP (same clone as 21860-1-PBS)

    WB analysis using 21860-1-AP (same clone as 21860-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 21860-1-AP (cyclin T2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21860-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 21860-1-AP (same clone as 21860-1-PBS)

    IHC staining of mouse brain using 21860-1-AP (same clone as 21860-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 21860-1-AP (cyclin T2 antibody) at dilution of 1:200 (under 4010x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21860-1-PBS in a different storage buffer formulation.

  • IHC staining of rat brain using 21860-1-AP (same clone as 21860-1-PBS)

    IHC staining of rat brain using 21860-1-AP (same clone as 21860-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 21860-1-AP (cyclin T2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21860-1-PBS in a different storage buffer formulation.

  • IHC staining of rat brain using 21860-1-AP (same clone as 21860-1-PBS)

    IHC staining of rat brain using 21860-1-AP (same clone as 21860-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 21860-1-AP (cyclin T2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21860-1-PBS in a different storage buffer formulation.

Cyclin T2 Polyclonal antibody, PBS Only

Cyclin T2 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 21860-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

CCNT2, Cyclin T, Cyclin-T2, CycT2

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

21860-1-PBS targets Cyclin T2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag16514

Product name: Recombinant human CCNT2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 251-610 aa of BC114366

Sequence: LKKIRNWRANQAARKPKVDGQVSETPLLGSSLVQNSILVDSVTGVPTNPSFQKPSTSAFPAPVPLNSGNISVQDSHTSDNLSMLATGMPSTSYGLSSHQEWPQHQDSARTEQLYSQKQETSLSGSQYNINFQQGPSISLHSGLHHRPDKISDHSSVKQEYTHKAGSSKHHGPISTTPGIIPQKMSLDKYREKRKLETLDLDVRDHYIAAQVEQQHKQGQSQAASSSSVTSPIKMKIPIANTEKYMADKKEKSGSLKLRIPIPPTDKSASKEELKMKIKVSSSERHSSSDEGSGKSKHSSPHISRDHKEKHKEHPSSRHHTSSHKHSHSHSGSSSGGSKHSADGIPPTVLRSPVGLSSDGI

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 cyclin T2
别名 CCNT2, Cyclin T, Cyclin-T2, CycT2
计算分子量 730 aa, 81 kDa
观测分子量 70 kDa
GenBank蛋白编号BC114366
基因名称 Cyclin T2
Gene ID (NCBI) 905
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO60583
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Cyclin T2 (CCNT2) belongs to the cyclin family. CCNT2 is regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II)  (PMID: 9499409, PMID: 15563843). Cyclin T2 is expressed at a relatively high level in freshly isolated monocytes and its level remains constant when the cells are induced to undergo macrophage differentiation (PMID: 21791050). In contrast, Cyclin T1 is expressed at low levels in monocytes and it is strongly up-regulated by a post-transcriptional mechanism when the cells are induced to differentiate to macrophages.

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