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diABZI STING agonist-1 (Tautomerism)

diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) 是一个选择性的干扰素基因刺激受体 (STING) 的激动剂，其在人和小鼠中的 EC50 值分别为 130 nM 和 186 nM。。

CAS号

2138498-18-5

分子式

C42H51N13O7

主要靶点

STING

仅限科研使用

Cat No : CM10450

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Synonyms

diABZI STING agonist (Compound 3)

验证数据展示

  • CAS No.: 2138498-18-5

    diABZI STING agonist-1 (Tautomerism)
    CAS#: 2138498-18-5

产品信息

diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.

CAS号 2138498-18-5
分子式 C42H51N13O7
主要靶点 STING
主要通路 免疫与炎症
分子量 849.94
纯度 99.72%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 diABZI STING agonist (Compound 3)

靶点活性

human STNG in PBMCs:130 nM (EC50)

体内活性

diABZI STING agonist-1 (Tautomerism)(subcutaneous injection; 2.5 mg/kg) induces STING-dependent activation of type I interferon and proinflammatory cytokines in vivo. diABZI STING agonist-1 (Tautomerism) (intravenous; 3 mg/kg) exhibited systemic exposure with a half-life of 1.4 hours and reached a systemic concentration greater than half the maximum effective concentration of STING in mice (EC50) 200 ng/kg) ml). diABZI STING agonist-1 (Tautomerism) (intravenous; 1.5 mg / kg; 43 days) can significantly inhibit tumor growth and significantly improve survival rate (P <0.001). Eight out of 10 mice are tumor-free[1].

体外活性

diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon gene (STING) receptor agonists, with EC50 of 130 and 186 nM for humans and mice, respectively. diABZI STING agonist-1 (Tautomerism) at a concentration of 1 μM showed high selectivity for more than 350 kinases tested[1].

溶解度

DMSO:126mg/mL (148.2mM),Sonification is recommended.

参考文献

1.Ramanjulu JM, et al. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature. 2018 Nov 7.

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