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Recombinant Human CD38 protein (Myc Tag, His Tag) (HPLC verified)

种属

Human

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

Myc Tag, His Tag

生物活性

未测试

Cat no : Eg0110

Print datasheet

Synonyms

2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, 2'-phospho-cyclic-ADP-ribose transferase, ADP ribosyl cyclase 1, ADPRC 1

验证数据展示

  • Purity of Recombinant Human CD38 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CD38 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Human CD38 was greater than 90% as determined by SEC-HPLC.

    The purity of Human CD38 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human CD38 protein Val43-Ile300 (Accession# P28907-1) with a Myc tag and a His tag at the C-terminus.
基因ID 952
蛋白编号 P28907-1
预测分子量 34.9 kDa
SDS-PAGE 38-55 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CD38, also known as ADP-ribosyl cyclase 1, is a type II transmembrane glycoprotein with a short N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. The extracellular domain of CD38 has bifunctional enzyme activities that catalyze synthesis of cyclic ADP ribose from nicotinamide adenine dinucleotide (NAD) and hydrolysis of cyclic ADP ribose to adenosine diphosphoribose. CD38 is expressed on a variety of hematopoietic and non-hematopoietic cells and is involved in diverse processes such as generation of calcium-mobilizing metabolites, cell activation, and chemotaxis. In addition to the membrane form, CD38 can also exist as a soluble form (sCD38), which is derived from the membrane form by proteolytic cleavage occurring near the cell membrane.

参考文献:

1. Jackson DG. et al. J Immunol. 1990;144(7):2811-2815.
2. Funaro A. et al.1996;8(11):1643-1650.
3. Cho YS. et al. J Biol Chem. 2000;275(3):1685-1690.
4. Lebedev MJ. et al. 2004;30(6):552-556.
5. Schneider M. et al. PLoS One. 2015;10(5):e0126007.