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  • Featured Product
  • KD/KO Validated

p120 Catenin Monoclonal antibody, PBS Only

p120 Catenin Monoclonal Antibody for WB, IHC, IF/ICC, IF-P, Indirect ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

human, mouse, rat

Applications

WB, IHC, IF/ICC, IF-P, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2F7H8

Cat no : 66208-1-PBS

Print datasheet

Synonyms

CTNND1, CTNND, Catenin delta-1, Catenin delta 1, CAS

验证数据展示

  • WB analysis of fetal human brain using 66208-1-Ig (same clone as 66208-1-PBS)

    WB analysis of fetal human brain using 66208-1-Ig (same clone as 66208-1-PBS)

    fetal human brain tissue were subjected to SDS PAGE followed by western blot with 66208-1-Ig (p120 Catenin antibody at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66208-1-PBS in a different storage buffer formulation.

  • IF Staining of human breast cancer using 66208-1-Ig (same clone as 66208-1-PBS)

    IF Staining of human breast cancer using 66208-1-Ig (same clone as 66208-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed human breast cancer tissue using 66208-1-Ig (p120 Catenin antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66208-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 66208-1-Ig (same clone as 66208-1-PBS)

    IHC staining of human breast cancer using 66208-1-Ig (same clone as 66208-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66208-1-Ig (p120 Catenin antibody) at dilution of 1:500 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66208-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with p120 Catenin antibody included
  • IHC staining of human breast cancer using 66208-1-Ig (same clone as 66208-1-PBS)

    IHC staining of human breast cancer using 66208-1-Ig (same clone as 66208-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66208-1-Ig (p120 Catenin antibody) at dilution of 1:500 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66208-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with p120 Catenin antibody included
  • IF Staining of MCF-7 using 66208-1-Ig (same clone as 66208-1-PBS)

    IF Staining of MCF-7 using 66208-1-Ig (same clone as 66208-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed MCF-7 cells using 66208-1-Ig (p120 Catenin antibody) at dilution of 1:100 and CoraLite488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66208-1-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy p120 Catenin Ready-To-Use IHC Kit. p120 Catenin primary antibody included.

产品信息

66208-1-PBS targets p120 Catenin in WB, IHC, IF/ICC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, IHC, IF/ICC, IF-P, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen p120 Catenin fusion protein Ag2824 种属同源性预测
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Full Name catenin (cadherin-associated protein), delta 1
Synonyms CTNND1, CTNND, Catenin delta-1, Catenin delta 1, CAS
Calculated Molecular Weight 948 aa, 105 kDa
Observed Molecular Weight 90-120 kDa
GenBank Accession NumberBC010501
Gene Symbol p120 Catenin
Gene ID (NCBI) 1500
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDO60716
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Catenins were discovered as proteins that are linked to the cytoplasmic domain of transmembrane cadherins (PMID: 9653641). p120 catenin, also called p120 ctn or catenin delta-1, regulates cell-cell adhesion through its interaction with the cytoplasmic tail of classical and type II cadherins. p120 catenin is a tyrosine kinase substrate implicated in cell transformation by SRC, as well as in ligand-induced receptor signaling through the EGF receptor, the PDGF receptor, and the CSF1 receptor. Different expression patterns of p120 catenin in lobular and ductal carcinomas of breast have been reported: membrane stain for ductal carcinoma and cytoplasmic stain for lobular carcinoma (PMID: 24966968). Different isoforms of p120 catenin are variably expressed in different tissues as a result of alternative splicing and the use of multiple translation initiation codons (PMID: 19150613).