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  • Featured Product
  • KD/KO Validated

p120 Catenin Monoclonal antibody, PBS Only

p120 Catenin Monoclonal Antibody for WB,Indirect ELISA,IHC,IF

Host / Isotype

Mouse / IgG2b

Reactivity

human, mouse, rat

Applications

WB,Indirect ELISA,IHC,IF

Conjugate

Unconjugated

CloneNo.

2F7H8

Cat No : 66208-1-PBS

Print datasheet

Synonyms

CAS, Catenin delta 1, CTNND, CTNND1, KIAA0384, p120, p120 Catenin, p120(cas), p120(ctn), P120CAS, p120-catenin, P120CTN

验证数据展示

  • WB analysis of fetal human brain using 66208-1-Ig (same clone as 66208-1-PBS)

    WB analysis of fetal human brain using 66208-1-Ig (same clone as 66208-1-PBS)

    fetal human brain tissue were subjected to SDS PAGE followed by western blot with 66208-1-Ig (p120 Catenin antibody at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66208-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 66208-1-Ig (same clone as 66208-1-PBS)

    IHC staining of human breast cancer using 66208-1-Ig (same clone as 66208-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66208-1-Ig (p120 Catenin antibody) at dilution of 1:500 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66208-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with p120 Catenin antibody included
  • IHC staining of human breast cancer using 66208-1-Ig (same clone as 66208-1-PBS)

    IHC staining of human breast cancer using 66208-1-Ig (same clone as 66208-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 66208-1-Ig (p120 Catenin antibody) at dilution of 1:500 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66208-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with p120 Catenin antibody included
  • IF Staining of MCF-7 using 66208-1-Ig (same clone as 66208-1-PBS)

    IF Staining of MCF-7 using 66208-1-Ig (same clone as 66208-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed MCF-7 cells using 66208-1-Ig (p120 Catenin antibody) at dilution of 1:100 and CoraLite488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66208-1-PBS in a different storage buffer formulation.

  • IF Staining of human breast cancer using 66208-1-Ig (same clone as 66208-1-PBS)

    IF Staining of human breast cancer using 66208-1-Ig (same clone as 66208-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed human breast cancer tissue using 66208-1-Ig (p120 Catenin antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66208-1-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy p120 Catenin Ready-To-Use IHC Kit. p120 Catenin primary antibody included.

产品信息

66208-1-PBS targets p120 Catenin in WB, IF, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB,Indirect ELISA,IHC,IF Application Description
Tested Reactivity human, mouse, rat
Immunogen p120 Catenin fusion protein Ag2824 种属同源性预测
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Full Name catenin (cadherin-associated protein), delta 1
Synonyms CAS, Catenin delta 1, CTNND, CTNND1, KIAA0384, p120, p120 Catenin, p120(cas), p120(ctn), P120CAS, p120-catenin, P120CTN
Calculated Molecular Weight 948 aa, 105 kDa
Observed Molecular Weight 90-120 kDa
GenBank Accession NumberBC010501
Gene Symbol CTNND1
Gene ID (NCBI) 1500
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDO60716
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

Catenins were discovered as proteins that are linked to the cytoplasmic domain of transmembrane cadherins (PMID: 9653641). p120 catenin, also called p120 ctn or catenin delta-1, regulates cell-cell adhesion through its interaction with the cytoplasmic tail of classical and type II cadherins. p120 catenin is a tyrosine kinase substrate implicated in cell transformation by SRC, as well as in ligand-induced receptor signaling through the EGF receptor, the PDGF receptor, and the CSF1 receptor. Different expression patterns of p120 catenin in lobular and ductal carcinomas of breast have been reported: membrane stain for ductal carcinoma and cytoplasmic stain for lobular carcinoma (PMID: 24966968). Different isoforms of p120 catenin are variably expressed in different tissues as a result of alternative splicing and the use of multiple translation initiation codons (PMID: 19150613).