p70(S6K) Monoclonal antibody, PBS Only (Capture)

p70(S6K) Monoclonal Antibody for WB, IHC, Cytometric bead array, Indirect ELISA
Cat No. 66638-1-PBS

产品说明书

CloneNo. 1D11C6

宿主/亚型

Mouse / IgG1

种属反应性

human, mouse, rat

应用

WB, IHC, Cytometric bead array, Indirect ELISA

Phospho-p70(S6K) (Thr389), p70 S6K, p70 S6 kinase, RPS6KB1, p70 S6K 1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -


Planning an IHC experiment? We recommend our IHCeasy RPS6KB1 Ready-To-Use IHC Kit. RPS6KB1 primary antibody included.

产品信息

66638-1-PBS targets p70(S6K) as part of a matched antibody pair:

MP50673-1: 66638-1-PBS capture and 66638-2-PBS detection (validated in Cytometric bead array)

Unconjugated mouse monoclonal antibody pair in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

经测试应用 WB, IHC, Cytometric bead array, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 p70(S6K) fusion protein Ag5883 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 ribosomal protein S6 kinase, 70kDa, polypeptide 1
别名 Phospho-p70(S6K) (Thr389), p70 S6K, p70 S6 kinase, RPS6KB1, p70 S6K 1
计算分子量 59 kDa
观测分子量60-75 kDa
GenBank蛋白编号BC053365
基因名称 p70 S6K
Gene ID (NCBI) 6198
RRIDAB_2881997
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDP23443
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

RPS6KB1(Ribosomal protein S6 kinase beta-1) is also named as STK14A, p70 S6KA and belongs to the S6 kinase subfamily. RPS6KB1 is a major substrate of MTOR and acts as a crucial effector of MTOR signaling pathway. It plays a key role in cell growth and proliferation by regulating INS sensitivity, metabolism, protein synthesis, and cell cycle. RPS6KB1 may play an important role in the progression of HCC and could serve as a potential molecular target for HCC therapy (PMID:22684641). RPS6KB1 is a 70 kDa protein and has 5 isoforms with the calculated molecular mass of 51-59kDa produced by alternative initiation.

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