验证数据展示
产品信息
60072-1-Ig targets Phospho-Akt (Tyr315) in WB, IF, ELISA applications and shows reactivity with human, mouse samples.
经测试应用 | ELISA Application Description |
文献引用应用 | WB, IF |
经测试反应性 | human, mouse |
文献引用反应性 | human, rat |
免疫原 | Phospho Peptide 种属同源性预测 |
宿主/亚型 | Mouse / IgG2b |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | v-akt murine thymoma viral oncogene homolog 1 |
别名 | |
计算分子量 | 56 kDa |
观测分子量 | 62 kDa |
GenBank蛋白编号 | NM_005163 |
基因名称 | AKT1 |
Gene ID (NCBI) | 207 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | P31749 |
储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Protein kinase B (PKB/Akt) has been well established as an important signaling intermediate, and its deregulation has been implicated in the development of human cancer and diabetes(PMID:12176337). Akt, also known as protein kinase B (PKB), is a serine/threonine kinase activated downstream of class I phosphatidylinositol 3-kinase (PI3K) and various receptors. It has emerged as the key regulator for many signal transduction pathways, modulating multiple processes such as cell survival, proliferation, growth, angiogenesis, and glucose metabolism(PMID:16139227). Its deregulation has been implicated in the development of human cancer and diabetes(PMID:12176337).
发表文章
Species | Application | Title |
---|---|---|
Sci Rep TCF7L2 involvement in estradiol- and progesterone-modulated islet and hepatic glucose homeostasis. | ||
Neuropharmacology Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition. | ||
Mar Drugs 11-epi-Sinulariolide Acetate Reduces Cell Migration and Invasion of Human Hepatocellular Carcinoma by Reducing the Activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR Signaling Pathways. | ||
PLoS One Ubiquitin B in cervical cancer: critical for the maintenance of cancer stem-like cell characters. | ||
Apoptosis SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells. | ||
Biochim Biophys Acta Nuclear PTEN interferes with binding of Ku70 at double-strand breaks through post-translational poly(ADP-ribosyl)ation. |