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uPAR/CD87 Monoclonal antibody, PBS Only

uPAR/CD87 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2A3E8

Cat no : 68727-1-PBS

Print datasheet

Synonyms

uPAR, PLAUR, PLAUR, UPAR, U PAR, MO3

验证数据展示

  • WB analysis of U2OS using 68727-1-Ig (same clone as 68727-1-PBS)

    WB analysis of U2OS using 68727-1-Ig (same clone as 68727-1-PBS)

    U2OS cells were subjected to SDS PAGE followed by western blot with 68727-1-Ig (uPAR/CD87 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68727-1-PBS in a different storage buffer formulation.

产品信息

68727-1-PBS targets uPAR/CD87 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human
Immunogen uPAR/CD87 fusion protein Ag28056 种属同源性预测
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Full Name PLAUR
Synonyms uPAR, PLAUR, PLAUR, UPAR, U PAR, MO3
Calculated Molecular Weight 37 kDa
Observed Molecular Weight35-50 kDa
GenBank Accession NumberBC002788
Gene Symbol uPAR
Gene ID (NCBI) 5329
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ03405
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

uPAR is a highly glycosylated, GPI-anchored membrane protein. In addition to the membrane-anchored form, uPAR is released from the plasma membrane by cleavage of the GPI anchor and can be found as a soluble form (suPAR). uPAR contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, uPA cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodeling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)