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验证数据展示

  • IHC staining of human colon cancer using 82953-1-RR (same clone as 82953-1-PBS)

    IHC staining of human colon cancer using 82953-1-RR (same clone as 82953-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 82953-1-RR (uPAR/CD87 antibody) at dilution of 1:400 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 82953-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 82953-1-RR (same clone as 82953-1-PBS)

    IHC staining of mouse brain using 82953-1-RR (same clone as 82953-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 82953-1-RR (uPAR/CD87 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 82953-1-PBS in a different storage buffer formulation.

  • IHC staining of human ovary cancer using 82953-1-RR (same clone as 82953-1-PBS)

    IHC staining of human ovary cancer using 82953-1-RR (same clone as 82953-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human ovary cancer tissue slide using 82953-1-RR (uPAR/CD87 antibody) at dilution of 1:400 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 82953-1-PBS in a different storage buffer formulation.

  • IF Staining of HT-1080 using 82953-1-RR (same clone as 82953-1-PBS)

    IF Staining of HT-1080 using 82953-1-RR (same clone as 82953-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HT-1080 cells using uPAR/CD87 antibody (82953-1-RR, Clone: 230148A1 ) at dilution of 1:400 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR002). This data was developed using the same antibody clone with 82953-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 82953-1-RR

    Affinity and Kinetic Characterization of 82953-1-RR

    Biolayer interferometry (BLl) kinetic assays of 82953-1-RR against Human uPAR, PLAUR were performed. The affinity constant is 1.49 nM.

uPAR/CD87 Recombinant antibody, PBS Only

uPAR/CD87 Uni-rAbTM Recombinant Antibody for IHC, IF/ICC, Indirect ELISA
Cat No. 82953-1-PBS

产品说明书

CloneNo. 230148A1

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

IHC, IF/ICC, Indirect ELISA

别名

uPAR, PLAUR, PLAUR, 230148A1, CD87, MO3

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

82953-1-PBS targets uPAR/CD87 in IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 uPAR/CD87 fusion protein Ag28056 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 PLAUR
别名 uPAR, PLAUR, PLAUR, 230148A1, CD87, MO3
计算分子量 37 kDa
GenBank蛋白编号BC002788
基因名称 uPAR
Gene ID (NCBI) 5329
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ03405
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

uPAR is a 45-65 kDa, highly glycosylated, GPI-anchored membrane protein. In addition to the membrane-anchored form, uPAR is released from the plasma membrane by cleavage of the GPI anchor and can be found as a soluble form (suPAR). uPAR contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, uPA cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodeling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)