- HEK293 expressed
- Endotoxin-free
- Animal-component free
HumanKine® recombinant human BMP-4 protein
Cat No : HZ-1045
Synonyms
BMP 2B, BMP 4, BMP2B, BMP2B1, BMP4, BMP-4, Bone morphogenetic protein 2B, bone morphogenetic protein 4, DVR4, MCOPS6, ZYME
Validation Data Gallery
Technical Specifications
GeneID | 652 |
Species | Human |
Expression | HEK293 |
Activity | 1.5-9 ng/mL EC50 |
Purity | >95% |
Endotoxin | <1 EU/µg |
Accession Number | P12644 |
Molecular Mass | 34 kDa, homodimer, glycosylated |
Formulation | 2x PBS + 6% Ethanol, See Certificate of Analysis for details |
Species Reactivity | human,mouse |
Stability and Reconstitution
Stability and Storage | Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin (HSA). |
Background
Bone morphogenetic protein-4 (BMP4), also known as BMP2B and DVR4, belongs to the TGF-beta family. BMPs have been shown to promote astroglial differentiation both in vitro and in vivo. BMP4 can also induce cartilage and bone formation (PMID 16234975). Xeno-free Recombinant Human BMP-4 is expressed in human 293 cells as a disulfide linked homodimeric glycoprotein with an apparent molecular mass of 34 kDa.
Synonyms
BMP 2B, BMP 4, BMP2B, BMP2B1, BMP4, BMP-4, Bone morphogenetic protein 2B, bone morphogenetic protein 4, DVR4, MCOPS6, ZYME
Publications
Species | Title |
---|---|
Stem Cell Res Ther Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells. | |
J Biol Chem Transforming growth factor β (TGF-β)-induced up-regulation of TGF-β receptors at the cell surface amplifies the TGF-β response. | |
Biotechnol Bioeng Optimized protocol for the hepatic differentiation of induced pluripotent stem cells in a fluidic microenvironment. | |
J Tissue Eng Regen Med Transplantation of multi-ciliated airway cells derived from human iPS cells using an artificial tracheal patch into rat trachea. | |
Mol Omics Analysis of the transcription factors and their regulatory roles during a step-by-step differentiation of induced pluripotent stem cells into hepatocyte-like cells. | |
Tissue Eng Part A Enhanced hepatic differentiation of human iPS cells using gas permeable membrane. |