OLIG2 (for WB only) Monoclonal antibody
OLIG2 (for WB only) Monoclonal Antibody for WB, ELISA
Host / Isotype
Mouse / IgG2a
Reactivity
Human and More (1)
Applications
WB, ELISA
Conjugate
Unconjugated
CloneNo.
1E8C5
验证数据展示
经过测试的应用
| Positive WB detected in | human brain tissue, human cerebellum tissue |
Planning an IHC experiment? We recommend our IHCeasy OLIG2 Ready-To-Use IHC Kit. OLIG2 primary antibody included.
推荐稀释比
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:6000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
发表文章中的应用
| WB | See 5 publications below |
产品信息
66513-1-Ig targets OLIG2 (for WB only) in WB, ELISA applications and shows reactivity with Human samples.
| Tested Applications | WB, ELISA Application Description |
| Cited Applications | WB |
| Tested Reactivity | Human |
| Cited Reactivity | human |
| Immunogen | OLIG2 (for WB only) fusion protein Ag18838 种属同源性预测 |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | oligodendrocyte lineage transcription factor 2 |
| Synonyms | BHLHB1, bHLHe19, OLIG2, OLIGO2, PRKCBP2, RACK17 |
| Calculated Molecular Weight | 32 kDa |
| Observed Molecular Weight | 35-39 kDa |
| GenBank Accession Number | BC047511 |
| Gene Symbol | OLIG2 |
| Gene ID (NCBI) | 10215 |
| RRID | AB_2881876 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q13516 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
OLIG2, also named as BHLHB1, BHLHE19, PRKCBP2 and RACK17, is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1, OLIG2 establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. OLIG2 is widely expressed in subsets of glia cells and progenitors, and it is strongly induced at different sites by both acute and chronic injury, albeit with different mechanisms. OLIG2 acts as a repressor of neurogenesis in cells reacting to brain injury. It may represent an effective approach towards evoking neuronal repair from parenchymal precursors.(PMID:19390819 )
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for OLIG2 (for WB only) antibody 66513-1-Ig | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
Cell Metab Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK | ||
Cell Biochem Funct Ring finger protein 216 loss-of-function induces white matter hyperintensities by inhibiting oligodendroglia proliferation | ||
Cell Metab Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation | ||
Commun Biol Selenoprotein W modulates tau homeostasis in an Alzheimer's disease mouse model | ||
Nucleic Acids Res A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma |
