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验证数据展示

  • WB analysis using 84973-1-RR

    WB analysis using 84973-1-RR

    Various lysates were subjected to SDS PAGE followed by western blot with 84973-1-RR (LRP4 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

  • Affinity and Kinetic Characterization of 84973-1-RR

    Affinity and Kinetic Characterization of 84973-1-RR

    Biolayer interferometry (BLl) kinetic assays of 84973-1-RR against Human LRP4 were performed. The affinity constant is 70.0 nM.

LRP4 Recombinant antibody

LRP4 Recombinant Antibody for WB, ELISA
Cat No. 84973-1-RR

产品说明书

CloneNo. 242157D11

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, ELISA

别名

LRP-4, LRP10, LRP 4, Low-density lipoprotein receptor-related protein 4, KIAA0816

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -

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经过测试的应用

Positive WB detected inrat brain tissue, mouse brain tissue, PC-3 cells

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:2000-1:10000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

84973-1-RR targets LRP4 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 LRP4 fusion protein Ag19413 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 low density lipoprotein receptor-related protein 4
别名 LRP-4, LRP10, LRP 4, Low-density lipoprotein receptor-related protein 4, KIAA0816
计算分子量 1905 aa, 212 kDa
观测分子量245 kDa
GenBank蛋白编号BC136667
基因名称 LRP4
Gene ID (NCBI) 4038
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDO75096
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

LRP4 (low-density lipoprotein receptor-related protein 4), also known as multiple epidermal growth factor-like domains 7 (MEGF7), is a type I single transmembrane protein of the low-density lipoprotein receptor (LDLR) family. LRP4 is composed of a large extracellular region containing multiple LDLa repeats, EGF-like domains and β-propeller domains, a transmembrane region and a cytoplasmic region containing an NPxY motif and a PDZ-interacting motif (PMID: 26071838). LRP4 binds agrin and recruits it to the MuSK signaling complex, which is critical for neuromuscular junction formation (PMID: 17119023; 18957220). LPR4 mutation or malfunction is implicated in disorders including congenital myasthenic syndrome, myasthenia gravis, and diseases of bone or kidney (26071838).

实验方案

Product Specific Protocols
WB protocol for LRP4 antibody 84973-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols