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LRP4 Recombinant antibody, PBS Only

LRP4 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

242157D11

Cat no : 84973-1-PBS

Print datasheet

Synonyms

LRP-4, LRP10, LRP 4, Low-density lipoprotein receptor-related protein 4, KIAA0816

验证数据展示

  • WB analysis using 84973-1-RR (same clone as 84973-1-PBS)

    WB analysis using 84973-1-RR (same clone as 84973-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84973-1-RR (LRP4 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84973-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84973-1-RR

    Affinity and Kinetic Characterization of 84973-1-RR

    Biolayer interferometry (BLl) kinetic assays of 84973-1-RR against Human LRP4 were performed. The affinity constant is 70.0 nM.

产品信息

84973-1-PBS targets LRP4 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen LRP4 fusion protein Ag19413 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name low density lipoprotein receptor-related protein 4
Synonyms LRP-4, LRP10, LRP 4, Low-density lipoprotein receptor-related protein 4, KIAA0816
Calculated Molecular Weight 1905 aa, 212 kDa
Observed Molecular Weight245 kDa
GenBank Accession NumberBC136667
Gene Symbol LRP4
Gene ID (NCBI) 4038
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDO75096
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

LRP4 (low-density lipoprotein receptor-related protein 4), also known as multiple epidermal growth factor-like domains 7 (MEGF7), is a type I single transmembrane protein of the low-density lipoprotein receptor (LDLR) family. LRP4 is composed of a large extracellular region containing multiple LDLa repeats, EGF-like domains and β-propeller domains, a transmembrane region and a cytoplasmic region containing an NPxY motif and a PDZ-interacting motif (PMID: 26071838). LRP4 binds agrin and recruits it to the MuSK signaling complex, which is critical for neuromuscular junction formation (PMID: 17119023; 18957220). LPR4 mutation or malfunction is implicated in disorders including congenital myasthenic syndrome, myasthenia gravis, and diseases of bone or kidney (26071838).