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Anti-Human KIM-1/HAVCR1 Rabbit Recombinant Antibody

KIM-1/HAVCR1 Uni-rAbTM Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

242001E8

Cat no : 98238-1-RR

Print datasheet

Synonyms

HAVCR1, KIM-1, TIM-1, KIM1, HAVcr-1

验证数据展示

  • FC experiment of HuH-7 using 98238-1-RR

    FC experiment of HuH-7 using 98238-1-RR

    1x10^6 HuH-7 cells (left) or 293-T cells (right) were surface stained with 0.25 ug Anti-Human KIM-1/HAVCR1 Rabbit Recombinant Antibody (98238-1-RR, Clone: 242001E8) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

  • Affinity and Kinetic Characterization of 98238-1-RR

    Affinity and Kinetic Characterization of 98238-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98238-1-RR against Human KIM-1/HAVCR1 were performed. The affinity constant is 0.366 nM.

经过测试的应用

Positive FC detected inHuH-7 cells

推荐稀释比

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

98238-1-RR targets KIM-1/HAVCR1 in FC applications and shows reactivity with human samples.

Tested Applications FC Application Description
Tested Reactivity human
Immunogen Recombinant protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name hepatitis A virus cellular receptor 1
Synonyms HAVCR1, KIM-1, TIM-1, KIM1, HAVcr-1
Calculated Molecular Weight39kDa
GenBank Accession NumberNM_001173393.3
Gene Symbol HAVCR1
Gene ID (NCBI) 26762
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ96D42
Storage Buffer PBS with 0.09% sodium azide, pH 7.3.
Storage ConditionsStore at 2 - 8°C. Stable for one year after shipment.

背景介绍

Kidney injury molecule 1 (KIM-1), also known as Hepatitis A virus cellular receptor 1 (HAVCR1), CD365, or T-cell immunoglobulin and mucin domain 1 (TIM-1), is a class I integral membrane glycoprotein, with an ectodomain containing Ig-like domain and a mucin domain. KIM-1 acts as a membrane receptor for hepatitis A virus (HAV) (PMID: 9658108; 8861957). KIM-1 provides a costimulatory signal for T cell activation and inhibits the development of peripheral tolerance (PMID: 16284246; 15793575). KIM-1 may be involved in the regulation of asthma and allergic diseases (PMID: 14534576). It has been reported that KIM-1 is shed into urine after acute kidney damage and is a marker of renal tubular injury (PMID: 14600030).

实验方案

Product Specific Protocols
FC protocol for KIM-1/HAVCR1 antibody 98238-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols