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11-​Keto-​beta-​boswellic acid

11-Keto-beta-boswellic acid 是来自乳香的一种五环三萜酸，具有抗炎活性和剂量依赖性心脏保护作用，主要是由于抑制5-脂氧合酶、白三烯、NF-κB 的激活和肿瘤坏死因子 α 的产生。

CAS号

17019-92-0

分子式

C30H46O4

主要靶点

Leukotriene Receptor|NF-κB|Lipoxygenase

仅限科研使用

Cat No : CM08367

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Synonyms

11-酮基-BETA-乳香酸|11-Keto-beta-boswellic acid

验证数据展示

  • CAS No.: 17019-92-0

    11-​Keto-​beta-​boswellic acid
    CAS#: 17019-92-0

产品信息

11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenase

CAS号 17019-92-0
分子式 C30H46O4
主要靶点 Leukotriene Receptor|NF-κB|Lipoxygenase
主要通路 G蛋白偶联受体|NF-κB信号通路|代谢
分子量 470.68
纯度 99.70%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 11-酮基-BETA-乳香酸|11-Keto-beta-boswellic acid

体外活性

A total of ten transformed compounds were isolated and purified, and their chemical structures were characterized as 7β-hydroxy-11-keto-β-boswellic acid; 7β, 15α±-dihydroxy-11-keto-β-boswellic acid ; 7β, 16β-dihydroxy-11-keto-β-boswellic acid; 7β, 16α±-dihydroxy-11-keto-β-boswellic acid; 7β, 22β-dihydroxy-11-keto-β-boswellic acid; 7β, 21β-dihydroxy-11-keto-β-boswellic acid; 7β, 20β-dihydroxy-11-keto-β-boswellic acid; 7β, 30-dihydroxy-11-keto-β-boswellic acid; 3α±, 7β-dihydroxy-11-oxours-12-ene-24, 30-dioic acid and 3α±, 7β-dihydroxy-30-(2-hydroxypropanoyloxy)-11-oxours-12-en-24-oic acid by various spectroscopic methods. The biotransformation processes include hydroxylation, oxidation and esterification. Primary structure-activity relationships (SAR) of inhibitory effects on NO production in RAW 264.7 macrophage cells are discussed[1]

溶解度

DMSO:22.5 mg/mL (47.8 mM)

参考文献

1.Biotransformation of 11-keto-β-boswellic acid by Cunninghamella blakesleana.Phytochemistry. 2013 Dec;96:330-6.

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