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ABCC5 Monoclonal antibody, PBS Only

ABCC5 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, Rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2H10F11

Cat no : 67955-1-PBS

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Synonyms

ABC33, ABCC5, DKFZp686C1782, EST277145, MOAT C, MOATC, MRP5, pABC11, SMRP

验证数据展示

  • WB analysis using 67955-1-Ig (same clone as 67955-1-PBS)

    WB analysis using 67955-1-Ig (same clone as 67955-1-PBS)

    Boiled and unboiled HepG2 lysates were subjected to SDS PAGE followed by western blot with 67955-1-Ig (ABCC5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67955-1-PBS in a different storage buffer formulation.

产品信息

67955-1-PBS targets ABCC5 in WB, Indirect ELISA applications and shows reactivity with Human, Rat samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human, Rat
Immunogen ABCC5 fusion protein Ag31674 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Synonyms ABC33, ABCC5, DKFZp686C1782, EST277145, MOAT C, MOATC, MRP5, pABC11, SMRP
Calculated Molecular Weight 161 kDa
Observed Molecular Weight180-200kDa
GenBank Accession NumberNM_005688
Gene Symbol ABCC5
Gene ID (NCBI) 10057
RRIDAB_2918706
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDO15440
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ABCC5, also named as MOAT-C, pABC11, SMRP, and MRP5, belongs to the ABC transporter superfamily, ABCC family, and Conjugate transporter (TC 3.A.1.208) subfamily. ABCC5 acts as a multispecific organic anion pump that can transport nucleotide analogs. ABCC5 functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that ABCC5 provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl) adenine. ABCC5 may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Since it is glycosylated, the apparent molecular weight of ABCC5 could be variable, ranging from 161 kDa to 200 kDa (PMID: 10893247; PMID: 15897250; PMID: 31338999).