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Species Reactivity
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Conjugate
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Conjugate
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验证数据展示

  • WB analysis using 67955-1-Ig (same clone as 67955-1-PBS)

    WB analysis using 67955-1-Ig (same clone as 67955-1-PBS)

    Boiled and unboiled HepG2 lysates were subjected to SDS PAGE followed by western blot with 67955-1-Ig (ABCC5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67955-1-PBS in a different storage buffer formulation.

ABCC5 Monoclonal antibody, PBS Only

ABCC5 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 67955-1-PBS

产品说明书

CloneNo. 2H10F11

宿主/亚型

Mouse / IgG1

种属反应性

Human, Rat

应用

WB, Indirect ELISA

别名

ABC33, ABCC5, DKFZp686C1782, EST277145, MOAT C, MOATC, MRP5, pABC11, SMRP

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

67955-1-PBS targets ABCC5 in WB, Indirect ELISA applications and shows reactivity with Human, Rat samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 Human, Rat
免疫原 ABCC5 fusion protein Ag31674 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
别名 ABC33, ABCC5, DKFZp686C1782, EST277145, MOAT C, MOATC, MRP5, pABC11, SMRP
计算分子量 161 kDa
观测分子量180-200kDa
GenBank蛋白编号NM_005688
基因名称 ABCC5
Gene ID (NCBI) 10057
RRIDAB_2918706
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDO15440
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ABCC5, also named as MOAT-C, pABC11, SMRP, and MRP5, belongs to the ABC transporter superfamily, ABCC family, and Conjugate transporter (TC 3.A.1.208) subfamily. ABCC5 acts as a multispecific organic anion pump that can transport nucleotide analogs. ABCC5 functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that ABCC5 provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl) adenine. ABCC5 may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Since it is glycosylated, the apparent molecular weight of ABCC5 could be variable, ranging from 161 kDa to 200 kDa (PMID: 10893247; PMID: 15897250; PMID: 31338999).