验证数据展示
产品信息
68017-1-PBS targets ACOX1 in WB, FC (Intra), ELISA applications and shows reactivity with human, mouse, rat, pig samples.
经测试应用 | WB, FC (Intra), ELISA Application Description |
经测试反应性 | human, mouse, rat, pig |
免疫原 | ACOX1 fusion protein Ag28037 种属同源性预测 |
宿主/亚型 | Mouse / IgG1 |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | acyl-Coenzyme A oxidase 1, palmitoyl |
别名 | Palmitoyl-CoA oxidase, EC:1.3.3.6, AOX, ACOX 1, ACOX |
计算分子量 | 74 kDa |
观测分子量 | 50 kDa |
GenBank蛋白编号 | BC010425 |
基因名称 | ACOX1 |
Gene ID (NCBI) | 51 |
RRID | AB_2918763 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | Q15067 |
储存缓冲液 | PBS Only |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
ACOX1(Peroxisomal acyl-coenzyme A oxidase 1) is the first and rate-limiting enzyme in the peroxisomal fatty acid beta-oxidation pathway and catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It belongs to the acyl-CoA oxidase family and also named as ACOX, AOX, SCOX. It has 3 isoforms produced by alternative splicing with the molecular mass of 70-74 kDa and can be cleaved post-translationally into a 50-kDa and a 22-kDa subunit between Val468 and Ala469 (PMID: 10672038). Defects in ACOX1 are the cause of adrenoleukodystrophy pseudoneonatal (Pseudo-NALD).