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ACVRL1 Monoclonal antibody, PBS Only

ACVRL1 Monoclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, Mouse

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2E11B10

Cat no : 66857-1-PBS

Print datasheet

Synonyms

Activin receptor like kinase 1, ACVRL1, ACVRLK1, ALK 1, ALK1, HHT, HHT2, ORW2, SKR3, TSR I

验证数据展示

  • WB analysis of HUVEC using 66857-1-Ig (same clone as 66857-1-PBS)

    WB analysis of HUVEC using 66857-1-Ig (same clone as 66857-1-PBS)

    HUVEC cells were subjected to SDS PAGE followed by western blot with 66857-1-Ig (ACVRL1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66857-1-PBS in a different storage buffer formulation.

  • IHC staining of human lymphoma using 66857-1-Ig (same clone as 66857-1-PBS)

    IHC staining of human lymphoma using 66857-1-Ig (same clone as 66857-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lymphoma tissue slide using 66857-1-Ig (ACVRL1 antibody) at dilution of 1:300 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66857-1-PBS in a different storage buffer formulation.

  • IHC staining of human lymphoma using 66857-1-Ig (same clone as 66857-1-PBS)

    IHC staining of human lymphoma using 66857-1-Ig (same clone as 66857-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lymphoma tissue slide using 66857-1-Ig (ACVRL1 antibody) at dilution of 1:300 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66857-1-PBS in a different storage buffer formulation.

产品信息

66857-1-PBS targets ACVRL1 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, Mouse samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity Human, Mouse
Immunogen ACVRL1 fusion protein Ag6446 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name activin A receptor type II-like 1
Synonyms Activin receptor like kinase 1, ACVRL1, ACVRLK1, ALK 1, ALK1, HHT, HHT2, ORW2, SKR3, TSR I
Calculated Molecular Weight 56 kDa
Observed Molecular Weight 56 kDa, 63 kDa
GenBank Accession NumberBC042637
Gene Symbol ACVRL1
Gene ID (NCBI) 94
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDP37023
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ACVRL1 (also known as ALK1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. ACVRL1 is highly expressed in endothelial cells and has a critical role in the control of blood vessel development and repair (PMID: 8640225). Mutations in the ACVRL1 gene are associated with hemorrhagic telangiectasia type 2.