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Host
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Species Reactivity
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Species Reactivity
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Conjugate
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Conjugate
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验证数据展示

  • WB analysis of HUVEC using 66857-1-Ig (same clone as 66857-1-PBS)

    WB analysis of HUVEC using 66857-1-Ig (same clone as 66857-1-PBS)

    HUVEC cells were subjected to SDS PAGE followed by western blot with 66857-1-Ig (ACVRL1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66857-1-PBS in a different storage buffer formulation.

  • IHC staining of human lymphoma using 66857-1-Ig (same clone as 66857-1-PBS)

    IHC staining of human lymphoma using 66857-1-Ig (same clone as 66857-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lymphoma tissue slide using 66857-1-Ig (ACVRL1 antibody) at dilution of 1:300 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66857-1-PBS in a different storage buffer formulation.

  • IHC staining of human lymphoma using 66857-1-Ig (same clone as 66857-1-PBS)

    IHC staining of human lymphoma using 66857-1-Ig (same clone as 66857-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lymphoma tissue slide using 66857-1-Ig (ACVRL1 antibody) at dilution of 1:300 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66857-1-PBS in a different storage buffer formulation.

ACVRL1 Monoclonal antibody, PBS Only

ACVRL1 Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 66857-1-PBS

产品说明书

CloneNo. 2E11B10

宿主/亚型

Mouse / IgG1

种属反应性

Human, Mouse

应用

WB, IHC, Indirect ELISA

别名

Activin receptor like kinase 1, ACVRL1, ACVRLK1, ALK 1, ALK1, HHT, HHT2, ORW2, SKR3, TSR I

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

66857-1-PBS targets ACVRL1 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, Mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 Human, Mouse
免疫原 ACVRL1 fusion protein Ag6446 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 activin A receptor type II-like 1
别名 Activin receptor like kinase 1, ACVRL1, ACVRLK1, ALK 1, ALK1, HHT, HHT2, ORW2, SKR3, TSR I
计算分子量 56 kDa
观测分子量 56 kDa, 63 kDa
GenBank蛋白编号BC042637
基因名称 ACVRL1
Gene ID (NCBI) 94
RRIDAB_2882196
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDP37023
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ACVRL1 (also known as ALK1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. ACVRL1 is highly expressed in endothelial cells and has a critical role in the control of blood vessel development and repair (PMID: 8640225). Mutations in the ACVRL1 gene are associated with hemorrhagic telangiectasia type 2.