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ACVRL1 Recombinant antibody, PBS Only

ACVRL1 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241686H2

Cat no : 84421-3-PBS

Print datasheet

Synonyms

ALK1, ALK 1, ACVRLK1, Activin receptor-like kinase 1, Activin receptor like kinase 1

验证数据展示

  • WB analysis of HUVEC using 84421-3-RR (same clone as 84421-3-PBS)

    WB analysis of HUVEC using 84421-3-RR (same clone as 84421-3-PBS)

    HUVEC cells were subjected to SDS PAGE followed by western blot with 84421-3-RR (ACVRL1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84421-3-PBS in a different storage buffer formulation.

产品信息

84421-3-PBS targets ACVRL1 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human
Immunogen FusionProtein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name activin A receptor type II-like 1
Synonyms ALK1, ALK 1, ACVRLK1, Activin receptor-like kinase 1, Activin receptor like kinase 1
Calculated Molecular Weight 56 kDa
Observed Molecular Weight63 kDa
GenBank Accession NumberBC042637
Gene Symbol ACVRL1
Gene ID (NCBI) 94
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP37023
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ACVRL1 (ALK1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. ACVRL1 is highly expressed in endothelial cells and has a critical role in the control of blood vessel development and repair (PMID: 8640225). Mutations in the ACVRL1 gene are associated with hemorrhagic telangiectasia type 2.