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ADRM1 Monoclonal antibody, PBS Only

ADRM1 Monoclonal Antibody for WB,Indirect ELISA,IF

Host / Isotype

Mouse / IgG3

Reactivity

human

Applications

WB,Indirect ELISA,IF

Conjugate

Unconjugated

CloneNo.

1A1A3

Cat No : 66464-1-PBS

Print datasheet

Synonyms

adhesion regulating molecule 1, ADRM1, ARM 1, ARM1, GP110, hRpn13, Rpn13, Rpn13 homolog

验证数据展示

  • WB analysis using 66464-1-Ig (same clone as 66464-1-PBS)

    WB analysis using 66464-1-Ig (same clone as 66464-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 66464-1-Ig (ADRM1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66464-1-PBS in a different storage buffer formulation.

  • IF Staining of HeLa using 66464-1-Ig (same clone as 66464-1-PBS)

    IF Staining of HeLa using 66464-1-Ig (same clone as 66464-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed HeLa cells using ADRM1 antibody (66464-1-Ig, Clone: 1A1A3 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 66464-1-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy ADRM1 Ready-To-Use IHC Kit. ADRM1 primary antibody included.

产品信息

66464-1-PBS targets ADRM1 in WB, IF, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB,Indirect ELISA,IF Application Description
Tested Reactivity human
Immunogen ADRM1 fusion protein Ag24699 种属同源性预测
Host / Isotype Mouse / IgG3
Class Monoclonal
Type Antibody
Full Name adhesion regulating molecule 1
Synonyms adhesion regulating molecule 1, ADRM1, ARM 1, ARM1, GP110, hRpn13, Rpn13, Rpn13 homolog
Calculated Molecular Weight 407 aa, 42 kDa
Observed Molecular Weight 42 kDa
GenBank Accession NumberBC017245
Gene Symbol ADRM1
Gene ID (NCBI) 11047
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ16186
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

The 26S proteasome is a key component of the ubiquitin-proteasome system, a process responsible for the majority of cellular protein degradation. hRpn13 (also termed ADRM1 or GP110) is a novel 46-kDa subunit of its 19S regulatory complex. hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity. Overexpression of hRpn13 promotes the activity of the ubiquitin-proteasome system and modulates the influence of osteoblasts on osteoclasts by controlling the stability of regulatory proteins in osteoblasts.