验证数据展示
产品信息
66464-1-PBS targets ADRM1 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.
经测试应用 | WB, IF/ICC, Indirect ELISA Application Description |
经测试反应性 | human |
免疫原 | ADRM1 fusion protein Ag24699 种属同源性预测 |
宿主/亚型 | Mouse / IgG3 |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | adhesion regulating molecule 1 |
别名 | adhesion regulating molecule 1, ADRM1, ARM 1, ARM1, GP110, hRpn13, Rpn13, Rpn13 homolog |
计算分子量 | 407 aa, 42 kDa |
观测分子量 | 42 kDa |
GenBank蛋白编号 | BC017245 |
基因名称 | ADRM1 |
Gene ID (NCBI) | 11047 |
RRID | AB_2881832 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | Q16186 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
The 26S proteasome is a key component of the ubiquitin-proteasome system, a process responsible for the majority of cellular protein degradation. hRpn13 (also termed ADRM1 or GP110) is a novel 46-kDa subunit of its 19S regulatory complex. hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity. Overexpression of hRpn13 promotes the activity of the ubiquitin-proteasome system and modulates the influence of osteoblasts on osteoclasts by controlling the stability of regulatory proteins in osteoblasts.