验证数据展示
产品信息
14631-1-PBS targets AFG3L2 in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
Tested Applications | WB, IHC, IF/ICC, IP, Indirect ELISA Application Description |
Tested Reactivity | human, mouse, rat |
Immunogen | AFG3L2 fusion protein Ag6209 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Full Name | AFG3 ATPase family gene 3-like 2 (yeast) |
Synonyms | |
Calculated Molecular Weight | 88 kDa |
Observed Molecular Weight | 80-90 kDa |
GenBank Accession Number | BC065016 |
Gene Symbol | AFG3L2 |
Gene ID (NCBI) | 10939 |
RRID | AB_2242420 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
UNIPROT ID | Q9Y4W6 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
AFG3L2 is the catalytic subunit of the m-AAA protease, an ATP-dependent proteolytic complex of the mitochondrial inner membrane that degrades misfolded proteins and regulates ribosome assembly(PMID:17101804). Human AFG3L2 is an 80-kDa protein encoded by a 17-exon gene and highly and selectively expressed in human cerebellar Purkinje cells(PMID:20208537) and it can exsit as a truncated 65 kDa protein(PMID:18337413). Defects in AFG3L2 are the cause of spinocerebellar ataxia type 28 (SCA28) and spastic ataxia autosomal recessive type 5 (SPAX5).