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AGK2

AGK2 是一种选择性SIRT2抑制剂，其IC50值为 3.5 μM。它抑制 SIRT1 和 SIRT3，IC50值分别为 30 和 91 μM。

CAS号

304896-28-4

分子式

C23H13Cl2N3O2

主要靶点

Sirtuin|Apoptosis

仅限科研使用

Cat No : CM06449

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Synonyms

2-氰基-3-[5-(2,5-二氯苯基)-2-呋喃基]-N-5-喹啉基-2-丙烯酰胺

验证数据展示

  • CAS No.: 304896-28-4

    AGK2
    CAS#: 304896-28-4

产品信息

AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.

CAS号 304896-28-4
分子式 C23H13Cl2N3O2
主要靶点 Sirtuin|Apoptosis
主要通路 表观遗传|DNA损伤和修复|凋亡
分子量 434.27
纯度 99.17%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 2-氰基-3-[5-(2,5-二氯苯基)-2-呋喃基]-N-5-喹啉基-2-丙烯酰胺

靶点活性

SIRT2:3.5 μM

体内活性

In drosophila model of parkinson's disease, AGK2 rescues α-Syn–mediated toxicity and modify aggregation. [1]

体外活性

In SIRT2-myc-expressing HeLa cells, AGK2 effectively inhibits the activity of SIRT2, and increases acetylated tubulin. AGK2 protects dopaminergic neurons from α-Syn–induced toxicity in primary midbrain cultures. [1] AGK2 induces both necrosis and caspase-3-dependent apoptosis in C6 glioma cells. [2] SIRT2 also decreases merlin-mutant viability of mouse schwann cells (MSCs) without substantially reducing wild-type MSC viability. [3]

溶解度

DMSO:4.3 mg/mL (10 mM)

参考文献

1.Outeiro TF, et al. Science.2007, 317(5837), 516-519. 2.He X, et al. Biochem Biophys Res Commun. 2012, 417(1), 468-472. 3.Petrilli A, et al. Oncotarget. 2013, 4(12), 2354-2365.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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=
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C1   V1   C2   V2