验证数据展示
产品信息
67785-1-PBS targets AHR in WB, IHC, IF/ICC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
经测试应用 | WB, IHC, IF/ICC, IF-P, Indirect ELISA Application Description |
经测试反应性 | human, mouse, rat |
免疫原 | AHR fusion protein Ag28935 种属同源性预测 |
宿主/亚型 | Mouse / IgG2b |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | aryl hydrocarbon receptor |
别名 | Class E basic helix-loop-helix protein 76, bHLHe76, Ah receptor, 2D1F9 |
计算分子量 | 848 aa, 96 kDa |
观测分子量 | 105-110 kDa |
GenBank蛋白编号 | BC070080 |
基因名称 | AHR |
Gene ID (NCBI) | 196 |
RRID | AB_2918549 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | P35869 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that has been largely regarded as a mediator of xenobiotic metabolism [PMID:18483242]. It plays a part role in physiologic activities, including attenuation of the acute phase response, cytokine signaling, T helper (TH)17 immune cell differentiation, modulation of NF-κB activity, and regulation of hormonal signaling [PMID:20423157,18540824]. It also mediates transcription factor sequestering away from a gene promoter or tethering of the AhR to a transcription factor on a promoter. AHR calculated molecular masses differ by <10%, compared with the apparent molecular masses predicted from SDS-PAGE for the two receptors (105 and 95 kDa, respectively). (PMID: 8246913)