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验证数据展示

  • WB analysis using 20590-1-AP (same clone as 20590-1-PBS)

    WB analysis using 20590-1-AP (same clone as 20590-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 20590-1-AP (AIM2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20590-1-PBS in a different storage buffer formulation.

  • IHC staining of human testis using 20590-1-AP (same clone as 20590-1-PBS)

    IHC staining of human testis using 20590-1-AP (same clone as 20590-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human testis using 20590-1-AP (AIM2 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 20590-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with AIM2 antibody included
  • WB analysis using 20590-1-AP (same clone as 20590-1-PBS)

    WB analysis using 20590-1-AP (same clone as 20590-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 20590-1-AP (AIM2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20590-1-PBS in a different storage buffer formulation.

  • IF Staining of MCF-7 using 20590-1-AP (same clone as 20590-1-PBS)

    IF Staining of MCF-7 using 20590-1-AP (same clone as 20590-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed MCF-7 cells using AIM2 antibody (20590-1-AP) at dilution of 1:400 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR002). This data was developed using the same antibody clone with 20590-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

AIM2 Polyclonal antibody, PBS Only

AIM2 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 20590-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy AIM2 Ready-To-Use IHC Kit. AIM2 primary antibody included.

产品信息

20590-1-PBS targets AIM2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原 AIM2 fusion protein Ag14520 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 absent in melanoma 2
别名
计算分子量 343 aa, 39 kDa
观测分子量 39-42 kDa
GenBank蛋白编号BC010940
基因名称 AIM2
Gene ID (NCBI) 9447
RRIDAB_10694420
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDO14862
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Absent in melanoma 2 (AIM2) is a sensor of cytosolic DNA that is responsible for activation of the inflammasome and host immune responses to DNA viruses and intracellular bacteria [PMID:22695634]. Upon binding to DNA, it is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Otherwise, it functions as a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity [PMID:16432157,20566831].