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  • Featured Product
  • KD/KO Validated

AIM2 Polyclonal antibody, PBS Only

AIM2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 20590-1-PBS

Print datasheet

Synonyms

验证数据展示

  • WB analysis using 20590-1-AP (same clone as 20590-1-PBS)

    WB analysis using 20590-1-AP (same clone as 20590-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 20590-1-AP (AIM2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20590-1-PBS in a different storage buffer formulation.

  • IHC staining of human testis using 20590-1-AP (same clone as 20590-1-PBS)

    IHC staining of human testis using 20590-1-AP (same clone as 20590-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human testis using 20590-1-AP (AIM2 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 20590-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with AIM2 antibody included
  • WB analysis using 20590-1-AP (same clone as 20590-1-PBS)

    WB analysis using 20590-1-AP (same clone as 20590-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 20590-1-AP (AIM2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20590-1-PBS in a different storage buffer formulation.

  • IF Staining of MCF-7 using 20590-1-AP (same clone as 20590-1-PBS)

    IF Staining of MCF-7 using 20590-1-AP (same clone as 20590-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed MCF-7 cells using AIM2 antibody (20590-1-AP) at dilution of 1:400 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR002). This data was developed using the same antibody clone with 20590-1-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy AIM2 Ready-To-Use IHC Kit. AIM2 primary antibody included.

产品信息

20590-1-PBS targets AIM2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen AIM2 fusion protein Ag14520 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name absent in melanoma 2
Synonyms
Calculated Molecular Weight 343 aa, 39 kDa
Observed Molecular Weight 39-42 kDa
GenBank Accession NumberBC010940
Gene Symbol AIM2
Gene ID (NCBI) 9447
RRIDAB_10694420
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDO14862
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Absent in melanoma 2 (AIM2) is a sensor of cytosolic DNA that is responsible for activation of the inflammasome and host immune responses to DNA viruses and intracellular bacteria [PMID:22695634]. Upon binding to DNA, it is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Otherwise, it functions as a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity [PMID:16432157,20566831].