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ASL Monoclonal antibody, PBS Only

ASL Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

Human, mouse, rat, pig

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1G9H3

Cat no : 67692-1-PBS

Print datasheet

Synonyms

argininosuccinate lyase, Arginosuccinase, ASAL, ASL

验证数据展示

  • WB analysis using 67692-1-Ig (same clone as 67692-1-PBS)

    WB analysis using 67692-1-Ig (same clone as 67692-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67692-1-Ig (ASL antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67692-1-PBS in a different storage buffer formulation.

  • WB analysis of LNCaP using 67692-1-Ig (same clone as 67692-1-PBS)

    WB analysis of LNCaP using 67692-1-Ig (same clone as 67692-1-PBS)

    LNCaP cells were subjected to SDS PAGE followed by western blot with 67692-1-Ig (ASL antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67692-1-PBS in a different storage buffer formulation.

  • WB analysis of K-562 using 67692-1-Ig (same clone as 67692-1-PBS)

    WB analysis of K-562 using 67692-1-Ig (same clone as 67692-1-PBS)

    K-562 cells were subjected to SDS PAGE followed by western blot with 67692-1-Ig (ASL antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67692-1-PBS in a different storage buffer formulation.

产品信息

67692-1-PBS targets ASL in WB, Indirect ELISA applications and shows reactivity with Human, mouse, rat, pig samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human, mouse, rat, pig
Immunogen ASL fusion protein Ag30517 种属同源性预测
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Full Name argininosuccinate lyase
Synonyms argininosuccinate lyase, Arginosuccinase, ASAL, ASL
Calculated Molecular Weight 55 kDa
Observed Molecular Weight50 kDa
GenBank Accession NumberBC008195
Gene Symbol ASL
Gene ID (NCBI) 435
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP04424
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Argininosuccinate lyase (ASL), one of the significant UC enzymes, catalyzes argininosuccinate cleavage to generate arginine and fumarate. Arginine is then catalyzed by arginase to ornithine and polyamines, which are found to promote cancer cell proliferation and growth. Importantly, ASL ectopic expression is closely associated with poor prognosis of colorectal cancer, hepatocellular. ASL is a member of the aspartase/fumarase superfamily. Enzymes of this superfamily share similar tetrameric structure and active site, though the sequence identities between different members are quite low (less than 20%). Members of this superfamily have been recognised as drug targets for microbial infections. ASL is a 464-amino-acid enzyme with a molecular mass of 49.7 kDa. (PMID: 22386318 PMID: 31018905)