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ASXL1 Recombinant antibody, PBS Only

ASXL1 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241563A5

Cat no : 84630-1-PBS

Print datasheet

Synonyms

Polycomb group protein ASXL1, KIAA0978, Additional sex combs-like protein 1, 241563A5

验证数据展示

  • WB analysis using 84630-1-RR (same clone as 84630-1-PBS)

    WB analysis using 84630-1-RR (same clone as 84630-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84630-1-RR (ASXL1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84630-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84630-1-RR

    Affinity and Kinetic Characterization of 84630-1-RR

    Biolayer interferometry (BLl) kinetic assays of 84630-1-RR against Human ASXL1 were performed. The affinity constant is 39.3 nM.

产品信息

84630-1-PBS targets ASXL1 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human
Immunogen ASXL1 fusion protein Ag10290 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name additional sex combs like 1 (Drosophila)
Synonyms Polycomb group protein ASXL1, KIAA0978, Additional sex combs-like protein 1, 241563A5
Calculated Molecular Weight84aa,10 kDa; 1541aa,165 kDa
Observed Molecular Weight200-220 kDa
GenBank Accession NumberBC064984
Gene Symbol ASXL1
Gene ID (NCBI) 171023
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ8IXJ9
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Additional sex combs-like 1 (ASXL1) is a member of the ASXL family, which is involved in epigenetic regulation. It is one of the mammalian Asx homologs. Mutations in the ASXL1 gene are frequently found in myeloid neoplasms, breast cancers, and prostate cancers (PMID: 30013160; PMID: 22436456; PMID: 26470845). In patients with myeloid malignancies, ASXL1 mutations are mostly heterozygous frameshift or nonsense mutations that result in C-terminal truncation (PMID: 30982744; PMID: 26095772; PMID: 32683582; PMID: 29643185).