验证数据展示
产品信息
83785-6-PBS targets ATOX1 in WB, FC (Intra), ELISA applications and shows reactivity with human samples.
经测试应用 | WB, FC (Intra), ELISA Application Description |
经测试反应性 | human |
免疫原 | ATOX1 fusion protein Ag18460 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | ATX1 antioxidant protein 1 homolog (yeast) |
别名 | ATX1, ATOX 1, Antioxidant 1, 240679E9 |
计算分子量 | 68 aa, 8 kDa |
观测分子量 | 7 kDa |
GenBank蛋白编号 | BC112248 |
基因名称 | ATOX1 |
Gene ID (NCBI) | 475 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purfication |
UNIPROT ID | O00244 |
储存缓冲液 | PBS Only |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Antioxidant 1 (ATOX1) is a copper chaperone to regulate copper homeostasis in cell. In the cytosol, ATOX1 always binds to copper and transfer to ATPase proteins in the trans-Golgi network, thereby promoting copper supply to various copper-dependent oxidereductases matured within the secretory vesicles (PMID: 28294521). Also, the protein could protect cells against oxidative damage and the expression levels of ATOX1 may help to the inflammatory response and antioxidant defense,even to modulate response to the cancer (PMID: 27472369). ATOX1 plays an important role in the physiology of the human central nervous system ,and it's highly expressed in the cerebral cortex and hippocampus (PMID: 30545441). Either cytosol or nucleus location of ATOX1 has been reported in different literations, which may be associated with cell status (PMID: 24445997; 31317143).