验证数据展示
产品信息
31697-1-PBS targets ATP8A2 in IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | IHC, IP, Indirect ELISA Application Description |
| 经测试反应性 | human, mouse |
| 免疫原 | ATP8A2 fusion protein Ag36276 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 |
| 别名 | |
| 计算分子量 | 133kDa |
| 观测分子量 | 129 kDa |
| GenBank蛋白编号 | NM_001313741 |
| 基因名称 | ATP8A2 |
| Gene ID (NCBI) | 51761 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity Purification |
| UNIPROT ID | Q9NTI2 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
ATP8A2 is also known as ATPIB. ATP8A2 is a member of the P4‐ATPase subfamily of P‐type ATPases that actively flips phosphatidylserine (PS) and phosphatidylethanolamine (PE) across membranes to generate and maintain transmembrane phospholipid asymmetry, a property important in such cellular processes as vesicle trafficking, apoptosis, cytokinesis, neuron survival, blood coagulation, and phagocytosis. ATP8A2 consists of an N‐domain involved in binding ATP, a P‐domain that undergoes phosphorylation, an A‐domain that functions in the dephosphorylation of the phosphorylated intermediate, and an M‐domain consisting of 10 transmembrane segments that comprise the pathway for translocation of the lipid across the membrane. ATP8A2 is highly expressed in the brain, spinal cord, testis, and retina (PMID: 33565221, PMID: 33766557, PMID: 37635783).
