验证数据展示
产品信息
67057-1-PBS targets ATX3,ATXN3 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with Human, mouse, pig samples.
| Tested Applications | WB, IHC, IF/ICC, Indirect ELISA Application Description |
| Tested Reactivity | Human, mouse, pig |
| Immunogen | ATX3,ATXN3 fusion protein Ag6627 种属同源性预测 |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | ataxin 3 |
| Synonyms | AT3, ataxin 3, ATX3, ATX3,ATXN3, ATXN3, JOS, MJD, MJD1, SCA3 |
| Calculated Molecular Weight | 370 aa, 43 kDa |
| Observed Molecular Weight | 41-45 kDa |
| GenBank Accession Number | BC033711 |
| Gene Symbol | ATXN3 |
| Gene ID (NCBI) | 4287 |
| RRID | AB_2882368 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P54252 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
ATXN3, which has deubiquitinase activity and act as a component of the ubiquitin proteasome system, plays a role in transcriptional regulation and neuroprotection. ATXN3 interacts with RAD23, HHR23A and HHR23B, involves in the pathology of MJD. ATXN3 is a mixed-linkage, chain-editing enzyme and that the UIM region of ATXN3 regulates its substrate specificity. Contains an N-terminal deubiquitinating domain, called the Josephin domain, followed by 2 ubiquitin-interacting motifs (UIMs) and a polyQ tract near the C terminus. ATXN3 can be phosphorylated in a protein casein kinase-2-dependent manner, thus the MW would be larger than the predicted one.
