• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

AXL Monoclonal antibody, PBS Only

AXL Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

3D12F11

Cat no : 68108-1-PBS

Print datasheet

Synonyms

UFO, Tyrosine-protein kinase receptor UFO, EC:2.7.10.1, 3D12F11

验证数据展示

  • WB analysis using 68108-1-Ig (same clone as 68108-1-PBS)

    WB analysis using 68108-1-Ig (same clone as 68108-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68108-1-Ig (AXL antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with Lamin B1 Monoclonal antibody (66095-1-Ig) as loading control. This data was developed using the same antibody clone with 68108-1-PBS in a different storage buffer formulation.

产品信息

68108-1-PBS targets AXL in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human
Immunogen AXL fusion protein Ag14401 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name AXL receptor tyrosine kinase
Synonyms UFO, Tyrosine-protein kinase receptor UFO, EC:2.7.10.1, 3D12F11
Calculated Molecular Weight 894 aa, 98 kDa
Observed Molecular Weight130-140 kDa
GenBank Accession NumberBC032229
Gene Symbol AXL
Gene ID (NCBI) 558
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
UNIPROT IDP30530
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Axl, also known as Ufo or Ark, is a receptor tyrosine kinase of the TAM (Tyro3, Axl and Mer) family. Axl is a single-pass type I membrane protein containing two fibronectin type-III domains, two Ig-like C2-type domains and one protein kinase domain. Axl mRNA is widely expressed with highest levels in the heart and skeletal muscle. Gas6 has been identified as a ligand for human Axl. Gas6/Axl signaling plays a role in cell survival, cell proliferation, migration and differentiation. It has been reported that 110-120 kDa non-glycosylated AXL protein can be detected(PMID: 31171001). Endogenous Axl is auto-phosphorylated and reacted with a tyrosine-phosphorylated protein of 140 kDa(PMID: 12730092).