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BAG3 Monoclonal antibody, PBS Only

BAG3 Monoclonal Antibody for WB, IF/ICC, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human, mouse, rabbit, pig, rat

Applications

WB, IF/ICC, ELISA

Conjugate

Unconjugated

CloneNo.

4G6C2

Cat no : 68076-1-PBS

Print datasheet

Synonyms

BAG 3, BAG3, BIS, CAIR 1, Docking protein CAIR 1

验证数据展示

  • WB analysis using 68076-1-Ig (same clone as 68076-1-PBS)

    WB analysis using 68076-1-Ig (same clone as 68076-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68076-1-Ig (BAG3 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68076-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 68076-1-Ig (same clone as 68076-1-PBS)

    IF Staining of HepG2 using 68076-1-Ig (same clone as 68076-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed HepG2 cells using BAG3 antibody (68076-1-Ig, Clone: 4G6C2 ) at dilution of 1:1000 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 68076-1-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy BAG3 Ready-To-Use IHC Kit. BAG3 primary antibody included.

产品信息

68076-1-PBS targets BAG3 in WB, IF/ICC, ELISA applications and shows reactivity with Human, mouse, rabbit, pig, rat samples.

Tested Applications WB, IF/ICC, ELISA Application Description
Tested Reactivity Human, mouse, rabbit, pig, rat
Immunogen BAG3 fusion protein Ag17608 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name BCL2-associated athanogene 3
Synonyms BAG 3, BAG3, BIS, CAIR 1, Docking protein CAIR 1
Calculated Molecular Weight 61 kDa
Observed Molecular Weight74 kDa
GenBank Accession NumberBC006418
Gene Symbol BAG3
Gene ID (NCBI) 9531
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDO95817
Storage Buffer PBS only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

BAG3 (Bcl2-associated athanogene 3) belongs to the BAG protein family, the co-chaperone that binds to Hsc70/Hsp70 through the BAG domain and modulates their activity in polypeptide folding. BAG3 contains also a WW domain and a proline-rich (PXXP) repeat, that mediate binding to partners different from Hsp70. Through interacting with different molecular partner, BAG3 influences several cell processes, such as apoptosis, autophagy and cell motility. BAG3 protein has been reported to sustain cell survival, resistance to therapy, and/or motility and metastatization in several tumor types, thus being identified as a potential target for anticancer therapies. In addition, defects in BAG3 are the cause of some myopathy.