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BCAM Recombinant antibody, PBS Only

BCAM Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241051C8

Cat no : 84038-3-PBS

Print datasheet

Synonyms

F8/G253 antigen, CD239, B-CAM cell surface glycoprotein, Basal cell adhesion molecule, Auberger B antigen

验证数据展示

  • WB analysis using 84038-3-RR (same clone as 84038-3-PBS)

    WB analysis using 84038-3-RR (same clone as 84038-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84038-3-RR (BCAM antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84038-3-PBS in a different storage buffer formulation.

产品信息

The immunogen of 84038-3-PBS is BCAM Fusion Protein expressed in E. coli.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human
Immunogen BCAM fusion protein Ag28181 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name basal cell adhesion molecule (Lutheran blood group)
Synonyms F8/G253 antigen, CD239, B-CAM cell surface glycoprotein, Basal cell adhesion molecule, Auberger B antigen
Calculated Molecular Weight 67 kDa
Observed Molecular Weight67 kDa, 78-85 kDa
GenBank Accession NumberBC050450
Gene Symbol BCAM
Gene ID (NCBI) 4059
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP50895
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Basal cell adhesion molecule (Lu/BCAM) is a membrane-bound glycoprotein of the immunoglobulin superfamily (IgSF), functioning as a receptor for the extracellular matrix protein, laminin. BCAM (Lutheran/basal cell-adhesion molecule, a glycoprotein) belongs to the immunoglobulin superfamily which contains both Lu blood group and BCAM tumor-associated antigens. Proteomics analysis suggests that BCAM might be a potential biomarker for pancreatic cancer (PMID: 19199705). BCAM, involved in cell adhesion and migration, can also promote tumor metastasis and has been elucidated to play a functional role in the metastasis of thyroid cancer and gastric cancer (PMID: 10728810, 35941663). De-glycosylated BCAM has a preidicted molecular weight of 67 kDa. Two BCAM glycoprotein (gp) isoforms are present on human RBCs, Lu (85 kDa) and Lu(v13) (78 kDa); they result from the alternative splicing of intron 13 and differ by the lengths of their cytoplasmic domains (PMID: 23160466).