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Species Reactivity
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Species Reactivity
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Conjugate
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Conjugate
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Compatible Species
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Conjugate
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验证数据展示

  • FC experiment of U266 using 98215-1-RR

    FC experiment of U266 using 98215-1-RR

    1x10^6 U266 cells (left) or HEK-293T (right) were surface stained with 0.25 ug Anti-Human BCMA/TNFRSF17 Rabbit Recombinant Antibody (98215-1-RR, Clone: 241731A11) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

  • Affinity and Kinetic Characterization of 98215-1-RR

    Affinity and Kinetic Characterization of 98215-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98215-1-RR against Human BCMA/TNFRSF17 were performed. The affinity constant is 0.20 nM.

Anti-Human BCMA/TNFRSF17 Rabbit Recombinant Antibody

BCMA/TNFRSF17 Uni-rAbTM Recombinant Antibody for FC
Cat No. 98215-1-RR

Print datasheet

CloneNo. 241731A11

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

TNFRSF17, CD269, BCMA, BCM, B-cell maturation protein

Formulation:  PBS and Azide
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size: 

-/ -

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经过测试的应用

Positive FC detected inU266 cells

推荐稀释比

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

98215-1-RR targets BCMA/TNFRSF17 in FC applications and shows reactivity with human samples.

Tested Applications FC Application Description
Tested Reactivity human
Immunogen Recombinant protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name tumor necrosis factor receptor superfamily, member 17
Synonyms TNFRSF17, CD269, BCMA, BCM, B-cell maturation protein
Calculated Molecular Weight 184 aa, 20 kDa
GenBank Accession NumberBC058291
Gene Symbol TNFRSF17
Gene ID (NCBI) 608
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ02223
Storage Buffer PBS with 0.09% sodium azide, pH 7.3.
Storage ConditionsStore at 2 - 8°C. Stable for one year after shipment.

背景介绍

BCMA (B cell maturation antigen), also known as TNFRSF17, is 20.2-kDa type III transmembrane glycoprotein and is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes and plasma cells, which may be important for B cell development and autoimmune response (PMID: 32943087; 9846698). BCMA has two agonist ligands: a proliferation-inducing ligand (APRIL) and BAFF. When BCMA binds to APRIL, it transmits signals of cell survival and proliferation (PMID: 27127303); when BCMA binds to BAFF, it mediates the activation of NF-kappaB and MAPK8/JNK (PMID: 36140254). It has been found that the overexpression and activation of BCMA are associated with multiple myeloma (MM) in preclinical models and humans, supporting its potential utility as a therapeutic target for MM (PMID: 32055000; 32943087).

实验方案

Product Specific Protocols
FC protocol for BCMA/TNFRSF17 antibody 98215-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols