验证数据展示
产品信息
66292-1-PBS targets BDNF in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.
经测试应用 | WB, IF/ICC, Indirect ELISA Application Description |
经测试反应性 | human |
免疫原 | BDNF fusion protein Ag11329 种属同源性预测 |
宿主/亚型 | Mouse / IgG2a |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | brain-derived neurotrophic factor |
别名 | Brain-derived neurotrophic factor, brain derived neurotrophic factor, BDNF precursor form, 1E5C5 |
计算分子量 | 247 aa, 28 kDa |
观测分子量 | 32 kDa |
GenBank蛋白编号 | BC029795 |
基因名称 | BDNF |
Gene ID (NCBI) | 627 |
RRID | AB_2881675 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | P23560 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
1) What is BDNF?
BDNF (brain-derived neurotrophic factor) is a small secreted growth factor that is important for the development and plasticity of the central nervous system and vital for long-term memory. Selected polymorphisms of BDNF have been shown to increase susceptibility to memory impairment and selected eating and mental disorders.
2) FAQs for BDNF
A) I can detect more than one band in my samples
BDNF is a neurotrophin that is a subject of maturation by proteolytic cleavage. The precursor protein (pre-proBDNF) is first cleaved to proBDNF (~34 kDa) by removing a signal peptide, and then to a mature form of BDNF (14 kDa). Additionally, (pre-)proBDNF can form dimers that run between 50 and 60 kDa, and a minor truncated form of proBDNF running at 28 kDa has also been reported (PMID: 11152678).