验证数据展示
产品信息
80488-1-PBS targets Beta Catenin in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with Human, Pig, Mouse, Rat, Zebrafish samples.
Tested Applications | WB, IHC, IF/ICC, Indirect ELISA Application Description |
Tested Reactivity | Human, Pig, Mouse, Rat, Zebrafish |
Immunogen | Peptide 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Full Name | catenin (cadherin-associated protein), beta 1, 88kDa |
Synonyms | b cat, B-catenin, Beta catenin, Catenin beta 1, CTNNB, CTNNB1, DKFZp686D02253, FLJ25606, FLJ37923, PRO2286 |
Calculated Molecular Weight | 781 aa, 86 kDa |
Observed Molecular Weight | 92 kDa |
GenBank Accession Number | BC058926 |
Gene Symbol | Beta Catenin |
Gene ID (NCBI) | 1499 |
ENSEMBL Gene ID | ENSG00000168036 |
RRID | AB_2918895 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | P35222 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
β-Catenin, also known as CTNNB1, is an evolutionarily conserved, multifunctional intracellular protein. β-Catenin is a 92-kDa protein, originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. The Wnt/β-catenin pathway is also involved in the activation of other intracellular messengers such as calcium fluxes, JNK, and SRC kinases. Deregulation of β-catenin activity is associated with multiple diseases including cancers. (PMID: 22617422; 18334222)