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验证数据展示

  • WB analysis using 80488-1-RR (same clone as 80488-1-PBS)

    WB analysis using 80488-1-RR (same clone as 80488-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 80488-1-RR (Beta Catenin antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 80488-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver cancer using 80488-1-RR (same clone as 80488-1-PBS)

    IHC staining of human liver cancer using 80488-1-RR (same clone as 80488-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 80488-1-RR (Beta Catenin antibody) at dilution of 1:2000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 80488-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with Beta Catenin antibody included
  • IHC staining of human liver cancer using 80488-1-RR (same clone as 80488-1-PBS)

    IHC staining of human liver cancer using 80488-1-RR (same clone as 80488-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 80488-1-RR (Beta Catenin antibody) at dilution of 1:2000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 80488-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with Beta Catenin antibody included
  • IF Staining of MCF-7 using 80488-1-RR (same clone as 80488-1-PBS)

    IF Staining of MCF-7 using 80488-1-RR (same clone as 80488-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed MCF-7 cells using Beta Catenin antibody (80488-1-RR, Clone: 2J24 ) at dilution of 1:500 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), Alpha Tubulin antibody (66031-1-Ig, Clone: 1E4C11, red). This data was developed using the same antibody clone with 80488-1-PBS in a different storage buffer formulation.

Beta Catenin Recombinant antibody, PBS Only

Beta Catenin Uni-rAbTM Recombinant Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 80488-1-PBS

产品说明书

CloneNo. 2J24

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat, pig, zebrafish

应用

WB, IHC, IF/ICC, Indirect ELISA

别名

2J24, b cat, B-catenin, beta-Catenin, Catenin beta 1

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy Beta Catenin Ready-To-Use IHC Kit. Beta Catenin primary antibody included.

产品信息

80488-1-PBS targets Beta Catenin in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, mouse, rat, pig, zebrafish samples.

经测试应用 WB, IHC, IF/ICC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat, pig, zebrafish
免疫原 Peptide 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 catenin (cadherin-associated protein), beta 1, 88kDa
别名 2J24, b cat, B-catenin, beta-Catenin, Catenin beta 1
计算分子量 781 aa, 86 kDa
观测分子量92 kDa
GenBank蛋白编号BC058926
基因名称 Beta Catenin
Gene ID (NCBI) 1499
ENSEMBL Gene IDENSG00000168036
RRIDAB_2918895
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDP35222
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

β-Catenin, also known as CTNNB1, is an evolutionarily conserved, multifunctional intracellular protein. β-Catenin is a 92-kDa protein, originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. The Wnt/β-catenin pathway is also involved in the activation of other intracellular messengers such as calcium fluxes, JNK, and SRC kinases. Deregulation of β-catenin activity is associated with multiple diseases including cancers. (PMID: 22617422; 18334222)