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C5 Polyclonal antibody, PBS Only

C5 Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 22492-1-PBS

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Synonyms

C5, C5b, C5, C5a, Complement C5 alpha chain, Complement C5, C5a anaphylatoxin

验证数据展示

  • WB analysis using 22492-1-AP (same clone as 22492-1-PBS)

    WB analysis using 22492-1-AP (same clone as 22492-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 22492-1-AP (C5 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22492-1-PBS in a different storage buffer formulation.

产品信息

22492-1-PBS targets C5 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen C5 fusion protein Ag17882 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name complement component 5
Synonyms C5, C5b, C5, C5a, Complement C5 alpha chain, Complement C5, C5a anaphylatoxin
Calculated Molecular Weight 1676 aa, 188 kDa
Observed Molecular Weight120 kDa, 70 kDa
GenBank Accession NumberBC113740
Gene Symbol C5
Gene ID (NCBI) 727
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen Affinity purified
UNIPROT IDP01031
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The complement system is an important effector that bridges the innate and adaptive immune systems. The fifth component of complement, C5, is part of the complement cascade and plays an important role in inflammation and cell killing. It consists of disulfide-linked alpha and beta polypeptide chains but can be cleaved into two active peptides (C5a and C5b) by C5 convertases. Mutations and defects in C5 are associated with severe recurrent infections. (PMID: 20010915; PMID: 8011297; PMID: 6554279)