验证数据展示
产品信息
67885-1-PBS targets CBFB in Indirect ELISA, WB applications and shows reactivity with rat, human samples.
经测试应用 | Indirect ELISA, WB Application Description |
经测试反应性 | rat, human |
免疫原 | CBFB fusion protein Ag31183 种属同源性预测 |
宿主/亚型 | Mouse / IgG1 |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | core-binding factor, beta subunit |
别名 | PEBP2 beta, PEA2-beta, Core-binding factor subunit beta, CBF-beta, CBF beta |
计算分子量 | 182 aa, 22 kDa |
GenBank蛋白编号 | BC018509 |
基因名称 | CBFB |
Gene ID (NCBI) | 865 |
RRID | AB_2918642 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein G purification |
UNIPROT ID | Q13951 |
储存缓冲液 | PBS only , pH 7.3 |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
CBFB (core binding factor subunit β), forms the heterodimeric complex core-binding factor (CBF). As a critical transcription factor, CBFB is frequently mutated in breast cancer and considered to be of significance in the pathogenesis of cancer.(PMID: 29932212) The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters.) It has calculated molecular weight around 22kDa.