验证数据展示
产品信息
66353-1-PBS targets CBLB in WB, IHC, IF/ICC, ELISA applications and shows reactivity with human, mouse, pig, rat samples.
Tested Applications | WB, IHC, IF/ICC, ELISA Application Description |
Tested Reactivity | human, mouse, pig, rat |
Immunogen | CBLB fusion protein Ag18757 种属同源性预测 |
Host / Isotype | Mouse / IgG3 |
Class | Monoclonal |
Type | Antibody |
Full Name | Cas-Br-M (murine) ecotropic retroviral transforming sequence b |
Synonyms | CBLB, Nbla00127, RING finger protein 56, RNF56, SH3 binding protein CBL B |
Calculated Molecular Weight | 982 aa, 109 kDa |
Observed Molecular Weight | 110 kDa |
GenBank Accession Number | BC032851 |
Gene Symbol | CBLB |
Gene ID (NCBI) | 868 |
RRID | AB_2881733 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q13191 |
Storage Buffer | PBS only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
CBLB(E3 ubiquitin-protein ligase CBL-B) is also known as RNF56 and plays a necessary role to prevent the inappropriate activation of NF-B in response to lipopolysaccharide and to polymicrobial sepsis. CBLB can be phosphorylated on tyrosine and serine residues upon TCR or BCR activation, and upon various types of cell stimulation.. It also has a crucial role in the prevention of chronic inflammation and autoimmunity. This protein has 3 isoforms produced by alternative splicing.