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验证数据展示

  • FC experiment of J774A.1 using 98194-1-RR (same clone as 98194-1-PBS)

    FC experiment of J774A.1 using 98194-1-RR (same clone as 98194-1-PBS)

    1x10^6 LPS and Brefeldin A treated J774A.1 cells were intracellularly stained with 0.25 ug Anti-Mouse CCL3 Rabbit Recombinant Antibody (98194-1-RR, Clone:241695B10) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-conjugated Goat Anti-Rabbit IgG. 1x10^6 untreated J774A.1 cells were intracellularly stained with 0.25 ug Anti-Mouse CCL3 Rabbit Recombinant Antibody (98194-1-RR, Clone: 241695B10) and PE-conjugated Goat Anti-Rabbit IgG (black, dashed). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C). This data was developed using the same antibody clone with 98194-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98194-1-RR

    Affinity and Kinetic Characterization of 98194-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98194-1-RR against Mouse CCL3 were performed. The affinity constant is 3.87 nM.

Anti-Mouse CCL3 Rabbit Recombinant Antibody, PBS Only

CCL3 Uni-rAbTM Recombinant Antibody for FC (Intra)
Cat No. 98194-1-PBS

产品说明书

CloneNo. 241695B10

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

FC (Intra)

别名

Mip1a, Macrophage inflammatory protein 1-alpha, L2G25B, Heparin-binding chemotaxis protein, C-C motif chemokine 3

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98194-1-PBS targets CCL3 in FC (Intra) applications and shows reactivity with mouse samples.

经测试应用 FC (Intra) Application Description
经测试反应性 mouse
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 chemokine (C-C motif) ligand 3
别名 Mip1a, Macrophage inflammatory protein 1-alpha, L2G25B, Heparin-binding chemotaxis protein, C-C motif chemokine 3
计算分子量10kd
GenBank蛋白编号NM_011337
基因名称 Ccl3
Gene ID (NCBI) 20302
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP10855
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Chemokine (C-C motif) ligand 3 (CCL3), also known as MIP-1α, belongs to the family of chemokines. CCL3 has been found in the central nervous system and its cognate receptors, CCR1 and CCR5, have been reported to be expressed by astrocytes, microglia and neurons. CCL3 and its receptors, CCR1 and CCR5, also contribute to the development of bone disease in multiple myeloma by supporting tumor growth and regulating osteoclast differentiation. CCL3 is also associated with the regulation of cell growth, angiogenesis, and metastasis of different tumors such as melanoma, renal cell carcinoma, and colorectal cancer. Moreover, CCL3 enhances cell migration and metastasis by up-regulating matrix metalloproteinase-2 (MMP)-2 expression in chondrosarcoma cells.