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CCR6 inhibitor 1

CCR6 inhibitor 1是一种有效的选择性CCR6抑制剂(猴子和人类CCR6的IC50分别为0.45和6 nM)。CCR6在自身免疫性疾病和非自身免疫性疾病中都有关联，因此CCR6 inhibitor 1 作为CCR6的小分子抑制剂对体外和体内病理生理学研究都有用。

CAS号

2437547-04-9

分子式

C24H23F3N4O3S

主要靶点

CCR

仅限科研使用

Cat No : CM09391

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Synonyms

验证数据展示

  • CAS No.: 2437547-04-9

    CCR6 inhibitor 1
    CAS#: 2437547-04-9

产品信息

CCR6 inhibitor 1 is an effective and selective inhibitor of CCR6 (IC50 of monkey and human CCR6 was 0.45 nM and 6 nM, respectively). CCR6 is associated with both autoimmune and non-autoimmune diseases, so CCR6 inhibitor 1 is useful for in vitro and in vivo pathophysiology studies as a small molecule inhibitor of CCR6.

CAS号 2437547-04-9
分子式 C24H23F3N4O3S
主要靶点 CCR
主要通路 微生物学|免疫与炎症
分子量 504.53
纯度 98.91%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

Moneky CCR6:0.45 nM|Human CCR7:9400 nM|Human CCR6:6 nM

体外活性

CCR6 inhibitor 1 in human CCR6-transfected CHO cells showed a good correlation between Gi signal inhibitory activity and cell migration inhibitory activity, which could effectively inhibit CCR6-dependent cell migration and ERK phosphorylation increase in human primary cells[1].

溶解度

DMSO:112.5 mg/mL (223.0 mM)

参考文献

1.Tawaraishi T, et al. Identification of a novel series of potent and selective CCR6 inhibitors as biological probes. Bioorg Med Chem Lett. 2018 Oct 1;28(18):3067-3072.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2