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CD107a / LAMP1 Recombinant antibody, PBS Only

CD107a / LAMP1 Uni-rAbTM Recombinant Antibody for IF/ICC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

242116E8

Cat no : 84658-5-PBS

Print datasheet

Synonyms

CD107a, LAMP1, LAMP-1, LAMP 1, CD107 antigen-like family member A

验证数据展示

  • IF Staining of HeLa using 84658-5-RR (same clone as 84658-5-PBS)

    IF Staining of HeLa using 84658-5-RR (same clone as 84658-5-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using CD107a / LAMP1 antibody (84658-5-RR, Clone: 242116E8 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 84658-5-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy LAMP1/CD107a Ready-To-Use IHC Kit. LAMP1/CD107a primary antibody included.

产品信息

84658-5-PBS targets CD107a / LAMP1 in IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications IF/ICC, Indirect ELISA Application Description
Tested Reactivity human
Immunogen Recombinant protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name lysosomal-associated membrane protein 1
Synonyms CD107a, LAMP1, LAMP-1, LAMP 1, CD107 antigen-like family member A
Calculated Molecular Weight45 kDa
GenBank Accession NumberNM_005561.4
Gene Symbol LAMP1
Gene ID (NCBI) 3916
ENSEMBL Gene IDENSG00000185896
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP11279-1
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

LAMP1 (CD107a) is a heavily glycosylated membrane protein enriched in the lysosomal membrane. LAMP1 is extensively glycosylated with asparagine-linked oligosaccharides which protect it from intracellular proteolysis (PMID: 10521503). Although LAMP1 is expressed largely in the endosome-lysosomal membrane of cells, it is also found on the plasma membrane (PMID: 16168398). Elevated LAMP1 expression at the cell surface has also been detected during platelet and granulocytic cell activation, as well as in some tumor cells (PMID: 29085473). LAMP1 functions to provide selectins with carbohydrate ligands. This protein has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells and may also play a role in tumor cell differentiation and metastasis (PMID: 18835598; 29085473; 9426697).