Anti-Human CD117/c-Kit (104D2)
CD117/c-Kit Monoclonal Antibody for FC
Host / Isotype
Mouse / IgG1, kappa
Reactivity
Human, Bovine
Applications
FC
Conjugate
Unconjugated
CloneNo.
104D2
验证数据展示
经过测试的应用
| Positive FC detected in | TF-1 cells |
Planning an IHC experiment? We recommend our IHCeasy CD117/c-kit Ready-To-Use IHC Kit. CD117/c-kit primary antibody included.
推荐稀释比
| Application | Dilution |
|---|---|
| This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
65154-1-Ig targets CD117/c-Kit in FC applications and shows reactivity with Human, Bovine samples.
| Tested Applications | FC Application Description |
| Tested Reactivity | Human, Bovine |
| Immunogen | MOLM-1 megakaryocytic cells 种属同源性预测 |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| Synonyms | C Kit, CD117, KIT, PBT, Proto oncogene c Kit, SCFR, Tyrosine protein kinase Kit |
| Calculated Molecular Weight | 976 aa, 110 kDa |
| GenBank Accession Number | BC071593 |
| Gene Symbol | CD117 |
| Gene ID (NCBI) | 3815 |
| RRID | AB_2918436 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Purified by protein-A affinity chromatography |
| UNIPROT ID | P10721 |
| Storage Buffer | PBS with 0.1% sodium azide. |
| Storage Conditions | Store at 2-8°C. Stable for one year after shipment. |
背景介绍
CD117, also known as c-Kit and SCFR, is a transmembrane protein with tyrosine kinase activity encoded by the oncogene c-kit (PMID: 2448137). It is a member of the type III receptor tyrosine kinase family, which also includes CSF-1R, PDGFRβ, PDGFRα, and FLT3 (PMID: 29518044). CD117 is expressed on hematopoietic stem cells and progenitor cells, mast cells, and is also found in a wide range of non-haemopoietic cell types (including melanocytes, germ cells, astrocytes, renal tubules, breast glandular epithelial cells, sweat glands, and interstitial cells of Cajal) (PMID: 10582338; 23073628). CD117 plays an important role in early haemopoiesis. It is also involved in pigmentation, fertility, gut movement, and some aspects of the nervous system (PMID: 23073628).
实验方案
| Product Specific Protocols | |
|---|---|
| FC protocol for CD117/c-Kit antibody 65154-1-Ig | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
