验证数据展示
经过测试的应用
Positive FC detected in | mouse splenocytes |
推荐稀释比
应用 | 推荐稀释比 |
---|---|
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
产品信息
98201-1-RR targets IFNGR1/CD119 in FC applications and shows reactivity with mouse samples.
经测试应用 | FC Application Description |
经测试反应性 | mouse |
免疫原 | Recombinant protein 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Recombinant |
产品类型 | Antibody |
全称 | interferon gamma receptor 1 |
别名 | IFN-gamma-R-alpha, IFN-gamma-R1, IFN-gamma receptor 1, IFN-gamma R1, CD119 |
计算分子量 | 52kDa |
GenBank蛋白编号 | NM_010511.3 |
基因名称 | Ifngr1 |
Gene ID (NCBI) | 15979 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purfication |
UNIPROT ID | P15261 |
储存缓冲液 | PBS with 0.09% sodium azide, pH 7.3. |
储存条件 | Store at 2 - 8°C. Stable for one year after shipment. |
背景介绍
Interferon-gamam (IFN-γ) is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Cellular responses to IFN-γ are activated through its interaction with a heterodimeric receptor consisting of two subunits, IFNGR1 (CD119) and IFNGR2. IFNGR1 is the ligand-binding subunit which binds IFN-γ with high affinity, whereas IFNGR2 serves as the accessory subunit. Two subunits bind one IFN-γ dimer. Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. (PMID: 17981204; 946248; 10888113)
实验方案
Product Specific Protocols | |
---|---|
FC protocol for IFNGR1/CD119 antibody 98201-1-RR | Download protocol |
Standard Protocols | |
---|---|
Click here to view our Standard Protocols |