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Anti-Human CD11c (BU15) Mouse IgG2a Recombinant Antibody, PBS Only

CD11c Recombinant Antibody for FC

Host / Isotype

Mouse / IgG2a

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

BU15

Cat no : 65600-1-PBS

Print datasheet

Synonyms

Leu M5, ITGAX, Integrin alpha-X, Integrin alpha X, CD11 antigen-like family member C

验证数据展示

  • FC experiment of human peripheral blood leukocyte using 65600-1-MR (same clone as 65600-1-PBS)

    FC experiment of human peripheral blood leukocyte using 65600-1-MR (same clone as 65600-1-PBS)

    1x10^6 human peripheral blood leukocyte were surface stained with 0.25 ug Anti-Human CD11c Mouse IgG2a Recombinant Antibody (65600-1-MR, Clone: BU15) or Mouse IgG2a Isotype Control (65208-1-Ig, Clone: C1.18.4) and CoraLite®488-Conjugated AffiniPure Donkey Anti-Mouse IgG(H+L). Cells were then stained with APC Anti-Human CD14. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 65600-1-PBS in a different storage buffer formulation.

  • FC experiment of human peripheral blood leukocyte using 65600-1-MR (same clone as 65600-1-PBS)

    FC experiment of human peripheral blood leukocyte using 65600-1-MR (same clone as 65600-1-PBS)

    1x10^6 human peripheral blood leukocyte were surface stained with 0.25 ug Anti-Human CD11c Mouse IgG2a Recombinant Antibody (65600-1-MR, Clone: BU15) (red) or Mouse IgG2a Isotype Control (65208-1-Ig, Clone: C1.18.4) (blue) and CoraLite®488-Conjugated AffiniPure Donkey Anti-Mouse IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 65600-1-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy CD11c Ready-To-Use IHC Kit. CD11c primary antibody included.

产品信息

65600-1-PBS targets CD11c in FC applications and shows reactivity with human samples.

Tested Applications FC Application Description
Tested Reactivity human
Immunogen Human synovial fluid dendritic cells 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Recombinant
Type Antibody
Full Name integrin, alpha X (complement component 3 receptor 4 subunit)
Synonyms Leu M5, ITGAX, Integrin alpha-X, Integrin alpha X, CD11 antigen-like family member C
Calculated Molecular Weight 1169 aa, 129 kDa
GenBank Accession NumberBC038237
Gene Symbol CD11c
Gene ID (NCBI) 3687
ENSEMBL Gene IDENSG00000140678
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11c, also known as integrin αX, is a type I transmembrane glycoprotein present on a variety of cells, including monocytes/macrophages, granulocytes, a subset of B cells, NK cells and dendritic cells (PMID: 2897326; 1680915; 1694698; 17389580). As a result of its high level of expression on most dendritic cells, CD11c is typically considered to be a marker of conventional dendritic cells (PMID: 27119555). CD11c forms an α/β heterodimer with CD18 (integrin β2). CD11c/CD18 acts as a receptor for fibrinogen and is important in monocyte adhesion and chemotaxis (PMID: 1671533).